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Association between arachidonate 5-lipoxygenase-activating protein (ALOX5AP) and lung function in a Korean population

Authors
Ro, M; Kim, S; Pyun, JA; Shin, C; Cho, NH; Lee, JY; Koh, I; Kwack, K
Citation
Scandinavian journal of immunology, 76(2):151-157, 2012
Journal Title
Scandinavian journal of immunology
ISSN
0300-94751365-3083
Abstract
Arachidonate 5-lipoxygenase-activating protein (ALOX5AP) plays a role in the 5-lipoxygenase (LO) pathway, which includes the LTC(4), LTD(4), LTE(4) and LTB(4). These leukotrienes are known causative factors of asthma, allergy, atopy and cardiovascular diseases. ALOX5AP lacks enzyme activity and acts by helping 5-LO function. In this study, healthy and general subjects who live in rural and urban areas of Korea were tested for the association of ALOX5AP polymorphisms with lung function. Lung function was also estimated by calculating the predicted values for forced expiratory volume in one second (FEV(1) _%PRED) and the proportion of the forced vital capacity exhaled in the first second (FEV(1) /FVC_PRED). The linear regression was adjusted for residence area, gender, age, height and smoking status. The analysis revealed associations between FEV(1) and the single-nucleotide polymorphism (SNP) rs9506352 and the haplotype TCAC (permuted P-value < 0.05). The linkage disequilibrium block that included the significant SNPs overlapped with SNPs that were revealed previously to associate with myocardial infarction and asthma and to affect lung function. This study is the first to demonstrate the association between lung function and ALOX5AP polymorphisms in a healthy and general population.
MeSH terms
5-Lipoxygenase-Activating Proteins/*geneticsAdultAgedAsian Continental Ancestry Group/geneticsFemaleGenetic LinkageHumansLung/*physiologyMaleMiddle Aged*Polymorphism, Single NucleotideSmoking
DOI
10.1111/j.1365-3083.2012.02712.x
PMID
22537113
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Preventive Medicine & Public Health
AJOU Authors
조, 남한
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