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Association of three sets of high-affinity IgE receptor (FcepsilonR1) polymorphisms with aspirin-intolerant asthma.
DC Field | Value | Language |
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dc.contributor.author | Palikhe, NS | - |
dc.contributor.author | Kim, SH | - |
dc.contributor.author | Cho, BY | - |
dc.contributor.author | Ye, YM | - |
dc.contributor.author | Hur, GY | - |
dc.contributor.author | Park, HS | - |
dc.date.accessioned | 2010-12-24T01:22:14Z | - |
dc.date.available | 2010-12-24T01:22:14Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0954-6111 | - |
dc.identifier.uri | http://repository.ajou.ac.kr/handle/201003/790 | - |
dc.description.abstract | BACKGROUND AND OBJECTIVE: The high-affinity IgE receptor comprises a tetramer of the ligand-binding alpha chain, a signal-augmenting beta chain, and a signal-transducing gamma chain dimer on mast cells. We hypothesized that the three subsets of the FCER1 gene may play a role in the development of the aspirin-intolerant asthma (AIA) phenotype and analyzed these genetic polymorphisms in association with clinical parameters in AIA patients.
SUBJECTS AND METHODS: Six polymorphisms of FCER1 (FCERIA-344C>T, FCER1A-95T>C, MS4A2-109T>C, MS4A2 E237G, FCER1G-237A>G, FCER1G-54G>T) were genotyped in 126 AIA patients compared to 177 patients with aspirin-tolerant asthma (ATA) and 222 normal health controls (NC). RESULTS: A significant difference in the genotype frequencies of FCER1G-237A>G was detected between AIA and ATA patients (p<0.05) both in co-dominant and recessive analysis models, whereas no significant relationships were identified between the frequencies of the other five single-nucleotide polymorphisms and AIA, ATA, and NC subjects. In addition, AIA patients carrying the homozygous AA genotype of FCER1G-237A>G exhibited significantly higher total serum IgE levels than did those with the GG/AG genotype (p=0.012). AIA patients expressing the CT/TT genotype at FCERIA-344C>T showed a higher prevalence of serum IgE specific to Staphylococcal enterotoxin A than did those with the CC genotype (p=0.008). CONCLUSION: The FCER1G-237A>G and FCERIA-344C>T polymorphisms may contribute to the development of AIA in a Korean population. | - |
dc.language.iso | en | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Anti-Inflammatory Agents, Non-Steroidal | - |
dc.subject.MESH | Antibodies, Bacterial | - |
dc.subject.MESH | Aspirin | - |
dc.subject.MESH | Asthma | - |
dc.subject.MESH | Bronchial Provocation Tests | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Forced Expiratory Volume | - |
dc.subject.MESH | Gene Frequency | - |
dc.subject.MESH | Genetic Predisposition to Disease | - |
dc.subject.MESH | Genotype | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunoglobulin E | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Polymorphism, Single Nucleotide | - |
dc.subject.MESH | Receptors, IgE | - |
dc.subject.MESH | Superantigens | - |
dc.title | Association of three sets of high-affinity IgE receptor (FcepsilonR1) polymorphisms with aspirin-intolerant asthma. | - |
dc.type | Article | - |
dc.identifier.pmid | 18595682 | - |
dc.identifier.url | http://linkinghub.elsevier.com/retrieve/pii/S0954-6111(08)00127-3 | - |
dc.contributor.affiliatedAuthor | 김, 승현 | - |
dc.contributor.affiliatedAuthor | 예, 영민 | - |
dc.contributor.affiliatedAuthor | 박, 해심 | - |
dc.type.local | Journal Papers | - |
dc.identifier.doi | 10.1016/j.rmed.2008.03.017 | - |
dc.citation.title | Respiratory medicine | - |
dc.citation.volume | 102 | - |
dc.citation.number | 8 | - |
dc.citation.date | 2008 | - |
dc.citation.startPage | 1132 | - |
dc.citation.endPage | 1139 | - |
dc.identifier.bibliographicCitation | Respiratory medicine, 102(8). : 1132-1139, 2008 | - |
dc.identifier.eissn | 1532-3064 | - |
dc.relation.journalid | J009546111 | - |
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