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Clinical evaluation of the computerized chronic urticaria-specific quality of life questionnaire in Korean patients with chronic urticaria

Ye, YM; Park, JW; Kim, SH; Choi, JH; Hur, GY; Lee, HY; Lee, EH; Park, HS
Clinical and experimental dermatology, 37(7):722-728, 2012
Journal Title
Clinical and experimental dermatology
BACKGROUND: Chronic urticaria (CU) is a common skin disorder that affects the well-being and quality of life (QOL) of patients. Recently, we developed and validated a questionnaire for measuring QOL in Korean patients with CU, called the Chronic Urticaria-Specific Quality of Life (CU-QOL) questionnaire.

AIM: To evaluate the clinical significance of a computerized version of the CU-QOL, in adult patients with CU.

METHODS: This was a cross-sectional observational study that enrolled 249 Korean patients with CU from five university hospitals and measured computerized CU-QOL scores and Urticaria Activity Score (UAS) simultaneously. The internal consistency of the computerized CU-QOL was analysed using Cronbach α. To identify clinical correlations between the CU-QOL and patient characteristics, the atopic status and serum autoantibodies, including antinuclear, antithyroglobulin and antimicrosome antibodies, were measured. Multiple linear regression models were used to identify CU-QOL predictors.

RESULTS: Cronbach α was 0.94 for the overall computerized CU-QOL score. The CU-QOL scores correlated significantly with the UAS (r= -0.49, P<0.001). Of the factors aggravating CU, delayed pressure, sunlight exposure and emotional stress significantly influenced the overall CU-QOL scores in the univariate analysis. Multivariate regression models indicated that UAS and emotional stress were significant predictors of the four domains and of the total CU-QOL scores.

CONCLUSIONS: The computerized CU-QOL is a convenient and valid tool for measuring QOL in patients with CU. This study suggests that UAS, dermatographism and emotional stress are strong CU-QOL predictors in Korean patients with CU.
MeSH terms
AdolescentAdultAgedAged, 80 and overAutoantibodies/analysisChronic DiseaseCross-Sectional StudiesFemaleHealth StatusHumansKoreaMaleMiddle AgedPsychometrics/*methods*Quality of LifeQuestionnaires/*standardsRegression Analysis*Software ValidationUrticaria/immunology/*psychologyYoung Adult
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Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
AJOU Authors
예, 영민박, 해심
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