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Histamine release and inflammatory cell infiltration in airway Mucosa in methylene diphenyl diisocyanate (MDI)-induced occupational asthma.

DC Field Value Language
dc.contributor.authorHur, GY-
dc.contributor.authorSheen, SS-
dc.contributor.authorKang, YM-
dc.contributor.authorKoh, DH-
dc.contributor.authorPark, HJ-
dc.contributor.authorYe, YM-
dc.contributor.authorYim, HE-
dc.contributor.authorKim, KS-
dc.contributor.authorPark, HS-
dc.date.accessioned2010-12-24T01:27:35Z-
dc.date.available2010-12-24T01:27:35Z-
dc.date.issued2008-
dc.identifier.issn0271-9142-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/791-
dc.description.abstractINTRODUCTION: Although methylene diphenyl diisocyanate (MDI) is widely used in industries, there have been few studies of the pathogenic mechanisms of MDI-induced occupational asthma (MDI-OA).



METHODS: We performed immunohistochemical analyses, measured inflammatory mediators and cytokines, and quantified histamine release (HR) from peripheral basophils in MDI-OA patients. Thirteen MDI-exposed workers (five MDI-OA, two MDI-induced esoinophilic bronchitis, and six asymptomatic exposed controls, AEC) were enrolled.



RESULTS AND DISCUSSION: Immunochemical analyses indicated significantly increased anti-eosinophilic cationic protein-stained cells in MDI-OA patients as compared with controls (P < 0.05). Sputum eosinophil cationic protein levels were increased after MDI-specific inhalation challenge test in MDI-OA/EB patients (P < 0.02). Sputum eosinophil counts were highly correlated with IL-8 and MMP-9 levels (P < 0.05 and P < 0.01, respectively). Basophil HR was significantly increased in MDI-OA patients after stimulations with anti-IgG4 and MDI-human serum albumin conjugates (both P < 0.05). Eosinophil activation is a major feature of airway inflammation in MDI-OA patients. Increased HR by MDI may contribute to the pathogenic mechanisms of MDI-OA.
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dc.language.isoen-
dc.subject.MESHAdult-
dc.subject.MESHAsthma-
dc.subject.MESHBasophils-
dc.subject.MESHBronchial Provocation Tests-
dc.subject.MESHBronchoscopy-
dc.subject.MESHCell Movement-
dc.subject.MESHCytokines-
dc.subject.MESHFemale-
dc.subject.MESHHistamine Release-
dc.subject.MESHHumans-
dc.subject.MESHImmunity, Mucosal-
dc.subject.MESHImmunohistochemistry-
dc.subject.MESHInflammation Mediators-
dc.subject.MESHIsocyanates-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHOccupational Exposure-
dc.subject.MESHRespiratory Mucosa-
dc.subject.MESHSkin Tests-
dc.subject.MESHTextile Industry-
dc.titleHistamine release and inflammatory cell infiltration in airway Mucosa in methylene diphenyl diisocyanate (MDI)-induced occupational asthma.-
dc.typeArticle-
dc.identifier.pmid18484168-
dc.contributor.affiliatedAuthor신, 승수-
dc.contributor.affiliatedAuthor박, 한정-
dc.contributor.affiliatedAuthor예, 영민-
dc.contributor.affiliatedAuthor임, 현이-
dc.contributor.affiliatedAuthor박, 해심-
dc.type.localJournal Papers-
dc.identifier.doi10.1007/s10875-008-9199-y-
dc.citation.titleJournal of clinical immunology-
dc.citation.volume28-
dc.citation.number5-
dc.citation.date2008-
dc.citation.startPage571-
dc.citation.endPage580-
dc.identifier.bibliographicCitationJournal of clinical immunology, 28(5). : 571-580, 2008-
dc.identifier.eissn1573-2592-
dc.relation.journalidJ002719142-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pulmonary & Critical Care Medicine
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
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