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The impact of total antioxidant capacity on pulmonary function in asthma patients

Authors
Yoon, SY; Kim, TB; Baek, S; Kim, S; Kwon, HS; Lee, YS; Lee, T; Jang, AS; Chang, YS; Cho, SH; Choi, BW; Park, JW; Nham, DH; Yoon, HJ; Cho, YJ; Park, CS; Moon, HB; Cho, YS; COREA Study Group
Citation
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 16(11):1544-1550, 2012
Journal Title
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
ISSN
1027-37191815-7920
Abstract
BACKGROUND: Oxidative stress, mediated by an imbalance between oxidants and antioxidants, contributes significantly to the pathogenesis of asthma.



OBJECTIVE: To evaluate the impact of serum total antioxidant capacity (TAC) on the pulmonary function of Korean asthma patients.



METHOD: A total of 104 adult asthma patients enrolled from the COREA (Cohort for Reality and Evolution of Adult Asthma in Korea) programme participated in the study. Baseline clinical parameters at enrolment, and the results of pulmonary function tests at baseline and 1 and 2 years after enrolment were collected. TAC at baseline was measured using a Trolox-equivalent antioxidant capacity assay. Patients were divided into two groups based on TAC levels, and various clinical parameters were compared.



RESULT: Serum TAC levels correlated with forced expiratory volume in 1 second (FEV(1)) at baseline (r = 0.22, P = 0.03). The group with higher baseline TAC levels maintained greater mean FEV(1) both 1 and 2 years after enrolment, even after adjusting for sex, age, height, weight, body mass index and smoking status.



CONCLUSION: These results suggest an important link between serum TAC levels and pulmonary function, indicating that higher TAC levels may be a biomarker for favourable prognosis in asthma patients.
MeSH terms
AdultAgedAntioxidants/*metabolism/pharmacologyAsthma/*physiopathologyBiological Markers/metabolismChromans/pharmacologyCohort StudiesCross-Sectional StudiesFemaleFollow-Up StudiesForced Expiratory VolumeHumansLongitudinal StudiesMaleMiddle Aged*Oxidative StressPrognosisProspective StudiesRepublic of KoreaRespiratory Function TestsTime Factors
DOI
10.5588/ijtld.12.0842
PMID
23044449
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
AJOU Authors
남, 동호
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