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Identifying genetic susceptibility to sensitization to cephalosporins in health care workers

Authors
Nam, YH; Kim, JE; Kim, SH; Jin, HJ; Hwang, EK; Shin, YS; Ye, YM; Park, HS
Citation
Journal of Korean medical science, 27(11):1292-1299, 2012
Journal Title
Journal of Korean medical science
ISSN
1011-89341598-6357
Abstract
Exposure to cephalosporins could cause occupational allergic diseases in health care workers (HCWs). We evaluated the prevalence of serum specific IgE and IgG antibodies to cephalosporin-human serum albumin (HSA) conjugate and to identify potential genetic risk factors associated with sensitization to cephalosporins in exposed HCWs. The study population consisted of 153 HCWs who had been exposed to antibiotics in a single university hospital and 86 unexposed healthy controls. A questionnaire survey of work-related symptoms (WRS) was administered. A skin-prick test (SPT) was performed, and serum-specific IgE and IgG antibodies to 3 commonly prescribed cephalosporins were measured by ELISA. Four single-nucleotide polymorphisms of the candidate genes related to IgE sensitization were genotyped. The prevalence of WRS to cephalosporins was 2.6%. The prevalence rates of serum-specific IgE and IgG antibodies to cephalosporins were 20.3% and 14.7%, respectively. The FcεR1β-109T > C polymorphism was significantly associated with IgE sensitization to cephalosporins in HCWs (P = 0.036, OR = 3.553; CI, 1.324-9.532). The in vitro functional assay demonstrated that the T allele of FcεR1β-109T had greater promoter activity than did the C allele (P C polymorphism may be a potential genetic risk factor for increased IgE sensitization to cephalosporins.
DOI
10.3346/jkms.2012.27.11.1292
PMID
23166408
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
Journal Papers > Research Organization > Regional Clinical Trial Center
AJOU Authors
김, 승현신, 유섭예, 영민박, 해심
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