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Learning from HSV-infected mice as a model of Behçet's disease

Authors
Sohn, S; Lee, ES; Bang, D
Citation
Clinical and experimental rheumatology, 30(3 Suppl 72):S96-103, 2012
Journal Title
Clinical and experimental rheumatology
ISSN
0392-856X1593-098X
Abstract
Several animal models of Behçet's disease (BD) have been proposed according to putative etiology. Among these models, the herpes simplex virus (HSV)-induced model produced the most similar disease attributes observe in patients. Inoculation of HSV type 1 to the scratched earlobe of mice produced the appropriate symptoms, including oral, genital, and skin ulcers, eye lesions, arthritis, and intestinal involvement. This HSV-induced BD model is the only continuously used model, to which various therapeutic modalities have been applied.
MeSH terms
AnimalsAntiviral Agents/pharmacologyBehcet Syndrome/drug therapy/genetics/immunology/pathology/*virologyDisease Models, AnimalDisease ProgressionHerpes Simplex/drug therapy/genetics/immunology/pathology/*virologyHerpesvirus 1, Human/drug effects/immunology/*pathogenicityHumansImmunosuppressive Agents/pharmacologyMiceRisk Factors
PMID
22766172
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Microbiology
Journal Papers > School of Medicine / Graduate School of Medicine > Dermatology
AJOU Authors
손, 성향이, 은소
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