81 233

Cited 8 times in

Induction of remission is difficult due to frequent relapse during tapering steroids in Korean patients with polymyalgia rheumatica

Authors
Kim, HA; Lee, J; Ha, YJ; Kim, SH; Lee, CH; Choi, HJ; Baek, HJ; Lim, MJ; Park, W; Choi, S; Hong, YS; Lee, YH; Koh, BR; Suh, CH
Citation
Journal of Korean medical science, 27(1):22-26, 2012
Journal Title
Journal of Korean medical science
ISSN
1011-89341598-6357
Abstract
Polymyalgia rheumatica is an inflammatory disease affecting elderly and involving the shoulder and pelvic girdles. No epidemiological study of polymyalgia rheumatica was conducted in Korea. We retrospectively evaluated patients with polymyalgia rheumatica followed up at the rheumatology clinics of 10 tertiary hospitals. In total 51 patients, 36 patients (70.6%) were female. Age at disease onset was 67.4 yr. Twenty-three patients (45.1%) developed polymyalgia rheumatica in winter. Shoulder girdle ache was observed in 45 patients (90%) and elevated erythrocyte sedimentation rate (> 40 mm/h) in 49 patients (96.1%). Initial steroid dose was 23.3 mg/d prednisolone equivalent. Time to normal erythrocyte sedimentation rate was 4.1 months. Only 8 patients (15.7%) achieved remission. Among 41 patients followed up, 28 patients (68.3%) had flare at least once. Number of flares was 1.5 ± 1.6. The frequency of flare was significantly lower in patients with remission (P = 0.02). In Korea, polymyalgia rheumatica commonly develops during winter. Initial response to steroid is fairly good, but the prognosis is not benign because remission is rare with frequent relapse requiring long-term steroid treatment.
MeSH terms
AgedAged, 80 and overAnti-Inflammatory Agents/administration & dosage/*therapeutic useBlood SedimentationCohort StudiesFemaleHumansMaleMiddle AgedPolymyalgia Rheumatica/*drug therapy/epidemiologyPrognosisRecurrenceRepublic of Korea/epidemiologyRetrospective StudiesSeasonsSteroids/administration & dosage/*therapeutic use
DOI
10.3346/jkms.2012.27.1.22
PMID
22219609
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Rheumatology
AJOU Authors
김, 현아서, 창희
Full Text Link
Files in This Item:
22-26.pdfDownload
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse