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C-reactive protein is a more sensitive and specific marker for diagnosing bacterial infections in systemic lupus erythematosus compared to S100A8/A9 and procalcitonin

Authors
Kim, HA; Jeon, JY; An, JM; Koh, BR; Suh, CH
Citation
The Journal of rheumatology, 39(4):728-734, 2012
Journal Title
The Journal of rheumatology
ISSN
0315-162X
Abstract
OBJECTIVE: C-reactive protein (CRP), S100A8/A9, and procalcitonin have been suggested as markers of infection in patients with systemic lupus erythematosus (SLE). We investigated the clinical significance of these factors for indication of infection in SLE.



METHODS: Blood samples were prospectively collected from 34 patients with SLE who had bacterial infections and 39 patients with SLE who had disease flares and no evidence of infection. A second set of serum samples was collected after the infections or flares were resolved.



RESULTS: CRP levels of SLE patients with infections were higher than those with flares [5.9 mg/dl (IQR 2.42, 10.53) vs 0.06 mg/dl (IQR 0.03, 0.15), p < 0.001] and decreased after the infection was resolved. S100A8/A9 and procalcitonin levels of SLE patients with infection were also higher [4.69 μg/ml (IQR 2.25, 12.07) vs 1.07 (IQR 0.49, 3.05) (p < 0.001) and 0 ng/ml (IQR 0-0.38) vs 0 (0-0) (p < 0.001), respectively]; these levels were also reduced once the infection disappeared. In the receiver-operating characteristics analysis of CRP, S100A8/A9, and procalcitonin, the area under the curve was 0.966 (95% CI 0.925-1.007), 0.732 (95% CI 0.61-0.854), and 0.667 (95% CI 0.534-0.799), respectively. CRP indicated the presence of an infection with a sensitivity of 100% and a specificity of 90%, with a cutoff value of 1.35 mg/dl.



CONCLUSION: Our data suggest that CRP is the most sensitive and specific marker for diagnosing bacterial infections in SLE.
MeSH terms
AdultBacterial Infections/*blood/*diagnosis/immunologyBiological Markers/bloodC-Reactive Protein/analysis/*metabolismCalcitonin/bloodCalgranulin A/bloodCalgranulin B/bloodFemaleHumansLupus Erythematosus, Systemic/immunology/*metabolism/microbiologyMaleOpportunistic Infections/blood/diagnosis/immunologyPredictive Value of TestsProtein Precursors/bloodYoung Adult
DOI
10.3899/jrheum.111044
PMID
22337236
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Rheumatology
AJOU Authors
김, 현아전, 자영서, 창희
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