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Dickkopf-1 level is lower in patients with ankylosing spondylitis than in healthy people and is not influenced by anti-tumor necrosis factor therapy

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dc.contributor.authorKwon, SR-
dc.contributor.authorLim, MJ-
dc.contributor.authorSuh, CH-
dc.contributor.authorPark, SG-
dc.contributor.authorHong, YS-
dc.contributor.authorYoon, BY-
dc.contributor.authorKim, HA-
dc.contributor.authorChoi, HJ-
dc.contributor.authorPark, W-
dc.date.accessioned2013-04-24T06:54:21Z-
dc.date.available2013-04-24T06:54:21Z-
dc.date.issued2012-
dc.identifier.issn0172-8172-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/7950-
dc.description.abstract(1) To compare the serum levels of Dickkopf-1 (DKK-1) and bone biomarkers in patients with ankylosing spondylitis (AS) and healthy controls. (2) To examine the effects of anti-tumor necrosis factor-α (TNF-α) therapy for 3 months on bone biomarkers in patients with AS. We measured the levels of DKK-1, osteocalcin, osteoprotegerin, and C-terminal telopeptide of type I collagen (CTX-1) in patients with AS and in healthy controls at baseline and 3 months after initiating anti-TNF-α therapy in AS patients. Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) scores were also measured before and after anti-TNF-α therapy in AS patients. Serum levels of DKK-1 were significantly lower in the AS patients than in the controls (P < 0.0001). Osteocalcin and osteoprotegerin levels were significantly higher in the AS patients than in the controls (P < 0.0001). Serum levels of DKK-1 were not changed after the 3-month anti-TNF-α therapy. Osteocalcin level increased (P < 0.0001), osteoprotegerin level and BASDAI scores decreased (P = 0.025 and P < 0.0001, respectively) significantly after the 3-months anti-TNF-α therapy. Serum DKK-1 level was lower in patients with AS than in healthy controls and did not change after 3 months of anti-TNF-α therapy in the AS patients despite the marked improvement in BASDAI scores. These findings suggest the low serum DKK-1 level is related to the pathogenesis of new bone formation in AS, which is resistant to TNF-α blocking therapy.-
dc.language.isoen-
dc.subject.MESHAdult-
dc.subject.MESHAntibodies, Monoclonal-
dc.subject.MESHAntibodies, Monoclonal, Humanized-
dc.subject.MESHBiological Markers-
dc.subject.MESHCase-Control Studies-
dc.subject.MESHCollagen Type I-
dc.subject.MESHDown-Regulation-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHImmunoglobulin G-
dc.subject.MESHImmunologic Factors-
dc.subject.MESHIntercellular Signaling Peptides and Proteins-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHOsteocalcin-
dc.subject.MESHOsteogenesis-
dc.subject.MESHOsteoprotegerin-
dc.subject.MESHPeptides-
dc.subject.MESHReceptors, Tumor Necrosis Factor-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHSeverity of Illness Index-
dc.subject.MESHSpondylitis, Ankylosing-
dc.subject.MESHTime Factors-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHTumor Necrosis Factor-alpha-
dc.titleDickkopf-1 level is lower in patients with ankylosing spondylitis than in healthy people and is not influenced by anti-tumor necrosis factor therapy-
dc.typeArticle-
dc.identifier.pmid21833531-
dc.contributor.affiliatedAuthor서, 창희-
dc.contributor.affiliatedAuthor김, 현아-
dc.type.localJournal Papers-
dc.identifier.doi10.1007/s00296-011-1981-0-
dc.citation.titleRheumatology international-
dc.citation.volume32-
dc.citation.number8-
dc.citation.date2012-
dc.citation.startPage2523-
dc.citation.endPage2527-
dc.identifier.bibliographicCitationRheumatology international, 32(8). : 2523-2527, 2012-
dc.identifier.eissn1437-160X-
dc.relation.journalidJ001728172-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Rheumatology
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