55 198

Cited 28 times in

Simultaneous mitochondrial Ca(2+) overload and proteasomal inhibition are responsible for the induction of paraptosis in malignant breast cancer cells

Authors
Yoon, MJ; Kim, EH; Kwon, TK; Park, SA; Choi, KS
Citation
Cancer letters, 324(2):197-209, 2012
Journal Title
Cancer letters
ISSN
0304-38351872-7980
Abstract
In this study, we investigated the role of Ca(2+) in curcumin-induced paraptosis, a cell death mode that is accompanied by dilation of mitochondria and the endoplasmic reticulum (ER). Curcumin induced mitochondrial Ca(2+) overload selectively in the malignant breast cancer cells, but not in the normal breast cell, contributing to the dilation of mitochondria/ER and subsequent paraptotic cell death. In addition, we found that simultaneous inhibition of the mitochondrial Na(+)/Ca(2+) exchanger (mNCX) and proteasomes can trigger a sustained mitochondrial Ca(2+) overload and effectively induce paraptosis in malignant breast cancer cells.
MeSH terms
Antineoplastic Agents, Phytogenic/*pharmacologyAntineoplastic Combined Chemotherapy Protocols/pharmacologyBoronic Acids/pharmacologyBreast Neoplasms/enzymology/*pathologyCalcium/*metabolismCell Death/drug effectsCell Line, TumorClonazepam/analogs & derivatives/pharmacologyCurcumin/*pharmacologyDose-Response Relationship, DrugEndoplasmic Reticulum/drug effects/metabolism/pathologyFemaleHumansMitochondria/*drug effects/metabolism/pathologyProtease Inhibitors/*pharmacologyProteasome Endopeptidase Complex/metabolism*Proteasome InhibitorsPyrazines/pharmacologySodium-Calcium Exchanger/antagonists & inhibitors/metabolismThiazepines/pharmacologyTime Factors
DOI
10.1016/j.canlet.2012.05.018
PMID
22634500
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Biochemistry & Molecular Biology
AJOU Authors
최, 경숙
Full Text Link
Files in This Item:
fulltext not available.txtDownload
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse