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Reference values for serum levels of insulin-like growth factor-I and insulin-like growth factor binding protein-3 in Korean children and adolescents

Authors
Hyun, SE; Lee, BC; Suh, BK; Chung, SC; Ko, CW; Kim, HS; Lee, KH; Yang, SW; Shin, CH; Hwang, JS; Kim, DH; Lim, BK; Kim, JD; Yoo, HW; Chung, WY; Park, MJ; Woo, YJ; Kim, CJ; Lee, DY; Kim, EY; Choi, JH; Han, HS; Hwang, IT
Citation
Clinical biochemistry, 45(1-2):16-21, 2012
Journal Title
Clinical biochemistry
ISSN
0009-91201873-2933
Abstract
OBJECTIVE: Measurements of serum insulin-like growth factor-I (IGF-I) and IGF binding protein-3 (IGFBP-3) are utilized in the diagnostic work-up and clinical management of children with growth disorders. We designed this study to establish the reference values of serum IGF-I and IGFBP-3 levels according to age, sex and pubertal stage in Korean children and adolescents.



METHODS: For the study, 1378 healthy Korean children and adolescents aged 0 to 17 years (722 boys, 656 girls) were randomly selected. Blood samples were collected, and the stored sera were assayed for IGF-I and IGFBP-3 using immunoradiometric assay (IRMA, Immunotech). The R 2.8.1 program (Bell Laboratories) was used to generate reference percentile curves for IGF-I and IGFBP-3 according to age, sex, and pubertal stage



RESULTS: Serum IGFBP-3 level was higher in girls compared to that in boys of the same ages throughout the pubertal period, whereas IGF-I was only higher for girls younger than 13 years of age. Serum levels of IGF-I and IGFBP-3 increased steadily with age in the prepubertal stage, followed by a progressive decline thereafter. Peak levels of serum IGF-I and IGFBP-3 were observed two years earlier in girls compared to those in boys (13 vs. 15 years of age, respectively). Serum IGF-I and IGFBP-3 concentrations were highest at Tanner stage IV in boys and girls, with a subsequent decline.



CONCLUSIONS: Our reference value model based on age, sex, and pubertal stage can improve the diagnostic utility of IGF-1 and IGFBP-3 levels in the evaluation and management of Korean children and adolescents with growth disorders.
MeSH terms
AdolescentChildChild, PreschoolFemaleGrowth Disorders/bloodHumansImmunoradiometric Assay/methodsInfantInfant, NewbornInsulin-Like Growth Factor Binding Protein 3/*bloodInsulin-Like Growth Factor I/*biosynthesisKoreaMaleReference Values
DOI
10.1016/j.clinbiochem.2011.10.003
PMID
22032863
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pediatrics & Adolescent Medicine
AJOU Authors
황, 진순
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