Cited 0 times in Scipus Cited Count

Obesity in aspirin-tolerant and aspirin-intolerant asthmatics.

DC Field Value Language
dc.contributor.authorJang, AS-
dc.contributor.authorPark, JS-
dc.contributor.authorPark, SW-
dc.contributor.authorKim, DJ-
dc.contributor.authorUh, ST-
dc.contributor.authorSeo, KH-
dc.contributor.authorKim, YH-
dc.contributor.authorPark, HS-
dc.contributor.authorPark, CS-
dc.date.accessioned2010-12-24T02:22:43Z-
dc.date.available2010-12-24T02:22:43Z-
dc.date.issued2008-
dc.identifier.issn1323-7799-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/798-
dc.description.abstractBACKGROUND AND OBJECTIVE: Obesity is an important factor in the development of asthma. Aspirin hypersensitivity affects 5-10% of asthmatics. The association between obesity and aspirin hypersensitivity in asthma is unclear. This study evaluated the association of BMI and asthma in patients with aspirin-tolerant asthma (ATA) and aspirin-intolerant asthma (AIA).



METHODS: Aspirin provocation tests were performed in 667 asthmatic patients and changes in FEV(1) were used to categorize patients as ATA or AIA. The BMI of asthmatics was graded using the percentile BMI of 406 normal controls.



RESULTS: Aspirin-induced changes in FEV(1)% ranged from 15% to 68%. Compared with the controls, the ATA group had a higher BMI (24.5 +/- 0.1 vs 23.8 +/- 0.2 kg/m(2), P = 0.001). The AIA group had a lower BMI. The aspirin-induced percentage fall in FEV(1) was inversely correlated with BMI in asthmatic patients (r = -0.094, P = 0.016). BMI was correlated with age and PC20, but not with FEV(1) in asthmatic patients. In a logistic regression adjusted for age, gender, and smoking status, FEV(1) and PC20 were associated with AIA with odds ratios of 0.986 and 0.586, respectively. BMI was associated with AIA with an odds ratio of 0.916.



CONCLUSIONS: Aspirin intolerance in asthmatics explains the lesser association with obesity. Obesity is not a risk factor in the development of asthma in patients with AIA.
-
dc.language.isoen-
dc.subject.MESHAdolescent-
dc.subject.MESHAdult-
dc.subject.MESHAge Distribution-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHAspirin-
dc.subject.MESHAsthma-
dc.subject.MESHBody Mass Index-
dc.subject.MESHBronchoconstriction-
dc.subject.MESHChild-
dc.subject.MESHCyclooxygenase Inhibitors-
dc.subject.MESHDrug Hypersensitivity-
dc.subject.MESHFemale-
dc.subject.MESHForced Expiratory Volume-
dc.subject.MESHHumans-
dc.subject.MESHKorea-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHObesity-
dc.subject.MESHPrevalence-
dc.subject.MESHRisk Factors-
dc.subject.MESHSex Distribution-
dc.subject.MESHSkin Tests-
dc.subject.MESHYoung Adult-
dc.titleObesity in aspirin-tolerant and aspirin-intolerant asthmatics.-
dc.typeArticle-
dc.identifier.pmid18699807-
dc.contributor.affiliatedAuthor박, 해심-
dc.type.localJournal Papers-
dc.identifier.doi10.1111/j.1440-1843.2008.01358.x-
dc.citation.titleRespirology (Carlton, Vic.)-
dc.citation.volume13-
dc.citation.number7-
dc.citation.date2008-
dc.citation.startPage1034-
dc.citation.endPage1038-
dc.identifier.bibliographicCitationRespirology (Carlton, Vic.), 13(7). : 1034-1038, 2008-
dc.identifier.eissn1440-1843-
dc.relation.journalidJ013237799-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
Files in This Item:
There are no files associated with this item.

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse