33 282

Cited 0 times in

Association between a TGFbeta1 promoter polymorphism and the phenotype of aspirin-intolerant chronic urticaria in a Korean population.

Authors
Park, HJ; Ye, YM; Hur, GY; Kim, SH; Park, HS
Citation
Journal of clinical pharmacy and therapeutics, 33(6):691-697, 2008
Journal Title
Journal of clinical pharmacy and therapeutics
ISSN
0269-47271365-2710
Abstract
BACKGROUND: Chronic urticaria/angioedema is a common phenotype in patients with aspirin sensitivity; however, its genetic mechanism is not understood. Transforming growth factor (TGF)beta1 is a key regulatory cytokine involved in allergic inflammation.



OBJECTIVE: We examined the association of a TGFbeta1 genetic polymorphism with aspirin-intolerant chronic urticaria (AICU) and aspirin-tolerant chronic urticaria (ATCU) in a Korean population.



METHODS: A promoter polymorphism in the TGFbeta1 gene, TGFbeta1 -509C>T, was analysed in 112 AICU patients, 153 ATCU patients and 457 normal controls (NC), and the frequency was compared among the groups. Serum TGFbeta1 levels were measured by ELISA.



RESULTS: The minor allele frequency of the -509C>T polymorphism was significantly higher in patients with AICU compared with the other two groups (P < 0.02 for AICU vs. NC; P < 0.05 for AICU vs. ATCU). Among the AICU patients, those with the T allele tended to have lower serum TGFbeta1 levels.



CONCLUSION: These findings suggest that the -509C>T polymorphism in the TGFbeta1 promoter may contribute to the development of the AICU phenotype.
MeSH terms
AdultAllelesAngioedema/chemically inducedAngioedema/geneticsAnti-Inflammatory Agents, Non-Steroidal/adverse effectsAspirin/adverse effects*Drug Hypersensitivity/genetics*Enzyme-Linked Immunosorbent AssayFemaleGene FrequencyHumansKorea/epidemiologyMaleMiddle AgedPhenotypePolymorphism, Genetic*Promoter Regions, GeneticTransforming Growth Factor beta1/genetics*Urticaria/chemically inducedUrticaria/geneticsYoung Adult
DOI
10.1111/j.1365-2710.2008.00957.x
PMID
19138248
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
Journal Papers > Research Organization > Regional Clinical Trial Center
AJOU Authors
박, 한정예, 영민김, 승현박, 해심
Full Text Link
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse