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HbA1c and glucose intolerance in obese children and adolescents

Authors
Lee, HS; Park, HK; Hwang, JS
Citation
Diabetic medicine : a journal of the British Diabetic Association, 29(7):e102-e105, 2012
Journal Title
Diabetic medicine : a journal of the British Diabetic Association
ISSN
0742-30711464-5491
Abstract
AIMS: Childhood obesity is associated with an increased likelihood for having impaired glucose tolerance, dyslipidaemia and diabetes. The aim of the study was to evaluate HbA(1c) as a screening test for impaired glucose tolerance in obese children and adolescents and identify the optimal HbA(1c) threshold.



METHODS: We studied 126 obese and overweight children (BMI > 85 th percentile for age and gender) 4-17 years of age referred to the endocrine clinic at Ajou University Hospital in Korea. All subjects underwent HbA(1c) and oral glucose tolerance test.



RESULTS: Thirty-four patients (27%) out of 126 had impaired glucose tolerance. Silent diabetes was diagnosed in 10 adolescents (7.9%). Based on the receiver operating characteristic curve, the optimal cut point of HbA(1c) related to impaired glucose tolerance diagnosed by oral glucose tolerance test was 40 mmol/mol (5.8%), which was associated with a 64.7% sensitivity and 61.6% specificity, with an area under the receiver operating characteristic curve of 0.651 (95% CI 0.529-0.772).



CONCLUSIONS: Obesity is associated with an increased risk of impaired glucose tolerance. An HbA(1c) value of 40 mmol/mol (5.8%) should be used as a screening tool to identify children and adolescents with impaired glucose tolerance.
MeSH terms
AdolescentBlood Glucose/*metabolismChildChild, PreschoolFasting/*bloodFemaleGlucose Intolerance/*blood/epidemiologyGlucose Tolerance TestHemoglobin A, Glycosylated/*metabolismHumansMaleMass ScreeningObesity/*blood/epidemiologyPredictive Value of TestsProspective StudiesROC CurveRepublic of Korea/epidemiologyRisk FactorsSensitivity and Specificity
DOI
10.1111/j.1464-5491.2012.03596.x
PMID
22273110
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pediatrics & Adolescent Medicine
AJOU Authors
이, 해상황, 진순
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