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Cerebral glucose metabolism in oculopalatal tremor.

Authors
Moon, SY; Cho, SS; Kim, YK; Kim, SE; Kim, JH; Kim, JS
Citation
European journal of neurology, 15(1):42-49, 2008
Journal Title
European journal of neurology
ISSN
1351-51011468-1331
Abstract
No study adopted the statistical parametric mapping (SPM) analyses of (18)F-fluorodeoxy glucose (FDG) PET in a large number of patients with oculopalatal tremor (OPT). To determine regional cerebral glucose metabolism in patients with OPT, nine patients with OPT underwent FDG-PET of the brain. Their glucose metabolism was compared with that of 50 normal controls (NC) by using SPM analyses. Three patients had bilateral and six showed unilateral pseudohypertrophic degeneration of the inferior olivary nucleus (ION) on MRI. Compared with NC, OPT patients did not show any metabolic derangement in the anterolateral medulla where the pseudohypertrophic ION locates. Instead, six patients with unilateral ION changes had hypometabolism in ipsilesional pontine tegmentum and hypermetabolism in contralesional thalamus. Their metabolic changes did not depend on the lateralization of ION changes. Our study failed to present any metabolic evidence for the role of ION in the generation of OPT. In part, the failure might originate from the different pathomechanism between OPT and pure palatal tremor or sensitivity/specificity issues of PET and SPM analyses. But, our results suggest that impaired cell groups of the paramedian tract and thalamic tremor cells may contribute to the generation of OPT.
MeSH terms
AdultAgedBrain/metabolismBrain/physiopathologyBrain/radionuclide imagingFluorodeoxyglucose F18/diagnostic useFunctional Laterality/physiologyGlucose/metabolism*HumansMaleMiddle AgedMyoclonus/metabolism*Myoclonus/physiopathologyMyoclonus/radionuclide imagingNeural Pathways/metabolismNeural Pathways/physiopathologyNeural Pathways/radionuclide imagingOlivary Nucleus/pathologyOlivary Nucleus/physiopathologyPons/metabolismPons/physiopathologyPons/radionuclide imagingPositron-Emission TomographyPredictive Value of TestsSensitivity and SpecificityThalamus/metabolismThalamus/physiopathologyThalamus/radionuclide imagingTremor/metabolism*Tremor/physiopathologyTremor/radionuclide imaging
DOI
10.1111/j.1468-1331.2007.01997.x
PMID
18005053
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Neurology
AJOU Authors
문, 소영
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