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Impact of complete cytoreduction leaving no gross residual disease associated with radical cytoreductive surgical procedures on survival in advanced ovarian cancer

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dc.contributor.authorChang, SJ-
dc.contributor.authorBristow, RE-
dc.contributor.authorRyu, HS-
dc.date.accessioned2013-04-29T02:14:34Z-
dc.date.available2013-04-29T02:14:34Z-
dc.date.issued2012-
dc.identifier.issn1068-9265-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/8056-
dc.description.abstractBACKGROUND: To analyze the impact of radical cytoreductive surgery-as part of primary tumor debulking-on the amount of residual tumor and survival in patients with advanced ovarian cancer and to evaluate the prognostic significance of no gross residual disease (RD) after surgery.



METHODS: Medical records of 203 patients with International Federation of Gynecology and Obstetrics (FIGO) stage IIIC-IV ovarian cancer were reviewed. All patients underwent primary cytoreductive surgery followed by taxane- and platinum-based chemotherapy. Various clinicopathologic characteristics were collected.



RESULTS: Of 203 patients, 119 patients underwent simple surgery, while radical surgery was performed in 84 patients. Advanced age (hazard ratio [HR] 1.04, 95 % confidence interval [CI] 1.02-1.06, P < 0.01), FIGO stage IV disease (HR 3.61, 95 % CI 1.48-8.83, P < 0.01), and grossly visible RD (HR 3.24, 95 % CI 1.90-5.53, P < 0.01) were identified as significant factors associated with poor prognosis in the entire cohort of 203 patients. Radical surgery (HR 0.56, 95 % CI 0.37-0.87, P = 0.01) was associated with improved survival. In the subgroup of patients with stage IIIC disease with peritoneal carcinomatosis, independent prognostic factors were advanced age (HR 1.04, 95 % CI 1.01-1.06, P = 0.01), radical surgery (HR 0.58, 95 % CI 0.35-0.96, P = 0.03), and grossly visible RD (HR 2.86, 95 % CI 1.55-5.30, P < 0.01). Patients with no gross RD had the longest overall survival (86 months) compared with RD 0.1-1 cm (46 months) and RD >1.0 cm (37 months) (P < 0.01).



CONCLUSIONS: No gross RD is associated with improved overall survival, and radical surgery was effective for achieving no gross RD.
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dc.language.isoen-
dc.titleImpact of complete cytoreduction leaving no gross residual disease associated with radical cytoreductive surgical procedures on survival in advanced ovarian cancer-
dc.typeArticle-
dc.identifier.pmid22766983-
dc.contributor.affiliatedAuthor장, 석준-
dc.contributor.affiliatedAuthor유, 희석-
dc.type.localJournal Papers-
dc.identifier.doi10.1245/s10434-012-2446-8-
dc.citation.titleAnnals of surgical oncology-
dc.citation.volume19-
dc.citation.number13-
dc.citation.date2012-
dc.citation.startPage4059-
dc.citation.endPage4067-
dc.identifier.bibliographicCitationAnnals of surgical oncology, 19(13). : 4059-4067, 2012-
dc.identifier.eissn1534-4681-
dc.relation.journalidJ010689265-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Obstetrics & Gynecology
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