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Effect of intravitreal bevacizumab (Avastin(®)) therapy in malignant hypertensive retinopathy: a report of two cases

DC Field Value Language
dc.contributor.authorKim, EY-
dc.contributor.authorLew, H-
dc.contributor.authorSong, JH-
dc.date.accessioned2013-04-29T03:58:08Z-
dc.date.available2013-04-29T03:58:08Z-
dc.date.issued2012-
dc.identifier.issn1080-7683-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/8064-
dc.description.abstractPURPOSE: Malignant hypertensive retinopathy is a rare, but serious, complication of uncontrolled systemic hypertension for which no treatment has been established yet. We report 2 patients with malignant hypertensive retinopathy who recovered promptly following intravitreal bevacizumab injection.



METHODS: Intravitreal bevacizumab (1.25 mg/0.05 mL) was injected in 4 eyes of 2 patients having malignant hypertensive retinopathy with optic disc edema, macular edema, and retinal exudates. A complete ophthalmic examination, including the best-corrected visual acuity (BCVA), central macular thickness (CMT) on optical coherence tomography (OCT), and fluorescein angiography (FAG), was performed before and after the treatments.



RESULTS: Two eyes in 1 patient received two intravitreal injections of bevacizumab, whereas 2 eyes in the other patient received a single treatment. All 4 eyes had improvement of macular edema on OCT at 1 month and decreased fluorescein leakage on FAG 3 months after the treatment, which led to improvements in the BCVA in 3 eyes. In 1 eye with foveal atrophy, no change in the BCVA occurred despite the improved macular edema on OCT.



CONCLUSIONS: The results suggest that intravitreal bevacizumab injections might be a useful adjunctive treatment of malignant hypertensive retinopathy in some selected cases. However, further studies are mandatory to determine the safety and the efficacy of such injections in this disease.
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dc.language.isoen-
dc.subject.MESHAdult-
dc.subject.MESHAngiogenesis Inhibitors-
dc.subject.MESHAntibodies, Monoclonal, Humanized-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHHypertension, Malignant-
dc.subject.MESHHypertensive Retinopathy-
dc.subject.MESHIntravitreal Injections-
dc.titleEffect of intravitreal bevacizumab (Avastin(®)) therapy in malignant hypertensive retinopathy: a report of two cases-
dc.typeArticle-
dc.identifier.pmid22149905-
dc.contributor.affiliatedAuthor유, 호민-
dc.contributor.affiliatedAuthor송, 지훈-
dc.type.localJournal Papers-
dc.identifier.doi10.1089/jop.2011.0113-
dc.citation.titleJournal of ocular pharmacology and therapeutics-
dc.citation.volume28-
dc.citation.number3-
dc.citation.date2012-
dc.citation.startPage318-
dc.citation.endPage322-
dc.identifier.bibliographicCitationJournal of ocular pharmacology and therapeutics, 28(3). : 318-322, 2012-
dc.identifier.eissn1557-7732-
dc.relation.journalidJ010807683-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Ophthalmology
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