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Overexpression of c-Met promotes invasion and metastasis of small oral tongue carcinoma

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dc.contributor.authorLim, YC-
dc.contributor.authorHan, JH-
dc.contributor.authorKang, HJ-
dc.contributor.authorKim, YS-
dc.contributor.authorLee, BH-
dc.contributor.authorChoi, EC-
dc.contributor.authorKim, CH-
dc.date.accessioned2013-04-29T06:49:06Z-
dc.date.available2013-04-29T06:49:06Z-
dc.date.issued2012-
dc.identifier.issn1368-8375-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/8088-
dc.description.abstractc-Met proto-oncogene, which is a receptor of ligand hepatocyte growth factor (HGF), has been associated with cancer cell invasion. There have been no reports on the relationship between the expression of c-Met and tumor invasion and metastasis in small (T(1-2)) squamous cell carcinoma of the oral tongue (SCCOT). We analyzed the relationship between c-Met expression and tumor invasion depth and lymph node metastasis in 71 surgically treated patients with small SCCOT using immunohistochemistry. Furthermore, we investigated the associations between the c-Met expression status and patient survival. In addition, we explored whether overexpression of c-Met enhances tumor growth and invasion of tongue cancer cells in vitro and in vivo. Positive immunohistochemical staining of c-Met was observed in 39 (55%) samples. Presence of neck metastasis, and >4mm depth of tumor invasion, strongly correlated with c-Met expression in small SCCOT both by the univariate and multivariate analysis (p<.05). The survival rates with c-Met expression were significantly shorter than for patients without c-Met expression (p<.05). Constitutive activation of c-Met enhanced migration and invasion of tongue cancer cells in vitro through the expressions of matrix metalloproteinase-1, -2, and -9, and promoted tongue cancer cell growth in vitro and in vivo. The results support the association of c-Met with the invasiveness and metastasis of small SCCOT.-
dc.language.isoen-
dc.titleOverexpression of c-Met promotes invasion and metastasis of small oral tongue carcinoma-
dc.typeArticle-
dc.identifier.pmid22704061-
dc.identifier.urlhttp://linkinghub.elsevier.com/retrieve/pii/S1368-8375(12)00174-1-
dc.contributor.affiliatedAuthor한, 재호-
dc.contributor.affiliatedAuthor김, 철호-
dc.type.localJournal Papers-
dc.identifier.doi10.1016/j.oraloncology.2012.05.013-
dc.citation.titleOral oncology-
dc.citation.volume48-
dc.citation.number11-
dc.citation.date2012-
dc.citation.startPage1114-
dc.citation.endPage1119-
dc.identifier.bibliographicCitationOral oncology, 48(11). : 1114-1119, 2012-
dc.identifier.eissn1879-0593-
dc.relation.journalidJ013688375-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
Journal Papers > School of Medicine / Graduate School of Medicine > Otolaryngology
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