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Comparison of the optimal effect-site concentrations of remifentanil for preventing cough during emergence from desflurane or sevoflurane anaesthesia

Authors
Cho, HB; Kim, JY; Kim, DH; Kim, DW; Chae, YJ
Citation
The Journal of international medical research, 40(1):174-183, 2012
Journal Title
The Journal of international medical research
ISSN
0300-06051473-2300
Abstract
OBJECTIVE: To compare the effect-site concentrations of remifentanil target-controlled infusion (TCI) that produced 50% and 95% of the maximal effect (EC50 and EC95, respectively) for preventing cough during emergence from desflurane or sevoflurane anaesthesia, in patients undergoing elective thyroidectomy.



METHODS: Adults undergoing elective thyroidectomy were randomized to receive anaesthesia with desflurane or sevoflurane. The EC50 and EC95 values for remifentanil TCI were determined using Dixon's up-and-down method and probit analysis with sigmoid curve.



RESULTS: In total, 48 patients aged 20-64 years were enrolled in the study. The EC50±SD of remifentanil TCI, determined by Dixon's up-and-down method, were 1.54±0.70 and 1.11±0.24 ng/ml for desflurane and sevoflurane, respectively. The EC95 of remifentanil TCI, analysed by probit analysis, were 2.88 ng/ml and 2.29 ng/ml for desflurane and sevoflurane, respectively. The effect-site concentration of remifentanil TCI for preventing cough during emergence from desflurane anaesthesia was not significantly higher than that observed for sevoflurane.



CONCLUSIONS: During emergence from anaesthesia, variations in effect-site concentrations of remifentanil for preventing cough are of limited importance as they do not generate significant differences in results.
MeSH terms
AdultAirway ExtubationAnalgesics, Opioid/pharmacology/therapeutic useAnesthesia/*adverse effects*Anesthesia Recovery PeriodAnesthetics, Inhalation/adverse effectsCough/*drug therapy/etiology/physiopathology/*prevention & controlDemographyDose-Response Relationship, DrugFemaleHemodynamics/drug effectsHumansIsoflurane/adverse effects/*analogs & derivativesMaleMethyl Ethers/*adverse effectsMiddle AgedPiperidines/pharmacology/*therapeutic useRecovery of Function/drug effectsThyroidectomy
DOI
10.1177/147323001204000118
PMID
22429357
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Anesthesiology & Pain Medicine
AJOU Authors
조, 한범김, 종엽김, 대희김, 도완채, 윤정
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