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Target-controlled infusion of remifentanil for laryngeal mask airway insertion during sevoflurane induction in adults

Authors
Kwak, HJ; Chae, YJ; Lee, KC; Kim, JY
Citation
The Journal of international medical research, 40(4):1476-1482, 2012
Journal Title
The Journal of international medical research
ISSN
0300-06051473-2300
Abstract
OBJECTIVE: This randomized, double-blind study investigated the suitable target effect-site concentration of remifentanil for laryngeal mask airway (LMA) insertion during inhalation induction with sevoflurane.



METHODS: Patients aged 18 - 60 years were randomly assigned to one of three groups receiving infusions of normal saline (control group), or infusions with target effect-site remifentanil concentrations of either 1 ng/ml (R1 group) or 2 ng/ml (R2 group), 1 min after the induction of anaesthesia with sevoflurane. LMA insertion was attempted 2 min after induction. Insertion conditions were graded using a six-variable, three-point scale (excellent, intermediate or poor).



RESULTS: A total of 102 patients were included. The proportion of patients ranked as excellent for the LMA insertion was significantly higher in groups R1 and R2 compared with the control group. The incidence of apnoea was significantly more frequent in the R2 group than in the control or R1 groups.



CONCLUSIONS: Compared with 1 ng/ml remifentanil or normal saline, target-controlled infusion of 2 ng/ml remifentanil significantly improved the LMA insertion conditions during sevoflurane inhalational induction, although apnoeic episodes were more frequently observed.
MeSH terms
AdolescentAdultAnalgesics, Opioid/*administration & dosage/adverse effects*Anesthesia, Inhalation*Anesthetics, InhalationApnea/chemically inducedBlood Pressure/drug effectsDouble-Blind MethodFemaleHeart Rate/drug effectsHumansInfusion Pumps*Laryngeal MasksMale*Methyl EthersMiddle AgedPiperidines/*administration & dosage/adverse effectsSurgical Procedures, ElectiveYoung Adult
DOI
10.1177/147323001204000426
PMID
22971499
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Anesthesiology & Pain Medicine
AJOU Authors
채, 윤정김, 종엽
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