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Prognostic impact of fascin-1 expression is more significant in advanced colorectal cancer

DC Field Value Language
dc.contributor.authorOh, SY-
dc.contributor.authorKim, YB-
dc.contributor.authorSuh, KW-
dc.contributor.authorPaek, OJ-
dc.contributor.authorMoon, HY-
dc.date.accessioned2013-05-01T23:56:29Z-
dc.date.available2013-05-01T23:56:29Z-
dc.date.issued2012-
dc.identifier.issn0022-4804-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/8127-
dc.description.abstractBACKGROUND: Fascin-1 is not expressed in normal colorectal epithelium, but is up-regulated in colorectal cancer. However, its exact biological mechanism remains unknown. The purpose of this study was to investigate the relationship of fascin-1 expression with the clinicopathologic parameters and its prognostic impact in advanced colorectal cancer.



MATERIALS AND METHODS: The immunohistochemical stainings for fascin-1, β-catenin, and Ki-67 labeling index were performed with 126 stage III colorectal cancer specimens.



RESULTS: Fascin-1 was found to be expressed in 74 (58.7%) of the 126 colorectal cancer specimens. Five-year survival rate was significantly low, whereas the distant recurrence rate was significantly high in patients with fascin-positive stage III colorectal cancer. There was no significant correlation between fascin-1 expression and clinicopathologic factors such as tumor size, nodal metastasis, pathologic stage, β-catenin expression, and Ki-67 labeling index. However, fascin-1 expression was an independent prognostic factor in multivariate analysis. Patients with N1 showed no significant difference in 5-y DFS and OS according to the fascin-1 expression (79.0% versus 60.5%, P = 0.113; 86.5% versus 78.8%, P = 0.566). Patients with N2 showed marginal difference in 5-y DFS and significant difference in 5-y OS according to the fascin-1 expression (59.4% versus 32.4%, P = 0.088; 81.2% versus 39.5%, P = 0.002).



CONCLUSIONS: This study suggests that fascin-1 expression in colorectal cancer may be clinically useful in predicting distant metastasis and poor survival, and we demonstrated that fascin-1 expression and N stage are significant independent prognostic factors for survival of colorectal cancer patients.
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dc.language.isoen-
dc.subject.MESHAdenocarcinoma/*diagnosis/*metabolism/pathology-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHCarrier Proteins/*metabolism-
dc.subject.MESHCell Proliferation-
dc.subject.MESHColorectal Neoplasms/*diagnosis/*metabolism/pathology-
dc.subject.MESH*Disease Progression-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMicrofilament Proteins/*metabolism-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Invasiveness/diagnosis/prevention & control-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHPredictive Value of Tests-
dc.subject.MESHPrognosis-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHTumor Markers, Biological/*metabolism-
dc.subject.MESHYoung Adult-
dc.subject.MESHbeta Catenin/metabolism-
dc.titlePrognostic impact of fascin-1 expression is more significant in advanced colorectal cancer-
dc.typeArticle-
dc.identifier.pmid20851411-
dc.identifier.urlhttp://linkinghub.elsevier.com/retrieve/pii/S0022-4804(10)00618-9-
dc.contributor.affiliatedAuthor오, 승엽-
dc.contributor.affiliatedAuthor김, 영배-
dc.contributor.affiliatedAuthor서, 광욱-
dc.type.localJournal Papers-
dc.identifier.doi10.1016/j.jss.2010.07.015-
dc.citation.titleThe Journal of surgical research-
dc.citation.volume172-
dc.citation.number1-
dc.citation.date2012-
dc.citation.startPage102-
dc.citation.endPage108-
dc.identifier.bibliographicCitationThe Journal of surgical research, 172(1):102-108, 2012-
dc.identifier.eissn1095-8673-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Surgery
Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
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