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The features of radiation induced lung fibrosis related with dosimetric parameters

Authors
Oh, YT; Noh, OK; Jang, H; Chun, M; Park, KJ; Kim, MH; Park, HJ
Citation
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 102(3):343-346, 2012
Journal Title
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
ISSN
0167-81401879-0887
Abstract
BACKGROUND AND PURPOSE: Radiation induced lung fibrosis (RILF) is a major complication after lung irradiation and is very important for long term quality of life and could result in fatal respiratory insufficiency. However, there has been little information on dosimetric parameters for radiotherapy planning in the aspect of RILF. The features of RILF related with dosimetric parameters were evaluated.



METHODS AND MATERIALS: Forty-eight patients with non-small cell lung carcinoma who underwent post-operative radiation therapy (PORT) without adjuvant chemotherapy were analyzed. The degree of lung fibrosis was estimated by fibrosis volume and the dosimetric parameters were calculated from the plan of 3-dimensional conformal radiotherapy.



RESULTS: The fibrosis volume and V-dose as dosimetric parameters showed significant correlation and the correlation coefficient ranged from 0.602 to 0.683 (P<0.01). The degree of the correlation line was steeper as the dose increase and threshold dose was not found. Mean lung dose (MLD) showed strong correlation with fibrosis volume (correlation coefficient = 0.726, P<0.01).



CONCLUSIONS: The fibrosis volume is continuously increased with V-dose as the reference dose increases. MLD is useful as a single parameter for comparing rival plans in the aspect of RILF.
MeSH terms
AdultAgedCarcinoma, Non-Small-Cell Lung/*radiotherapyFemaleHumansLung Neoplasms/*radiotherapyMaleMiddle AgedPulmonary Fibrosis/*etiology/pathologyRadiation Injuries/*etiology/pathologyRadiotherapy Dosage
DOI
10.1016/j.radonc.2012.02.003
PMID
22342420
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Radiology
Journal Papers > School of Medicine / Graduate School of Medicine > Pulmonary & Critical Care Medicine
Journal Papers > School of Medicine / Graduate School of Medicine > Radiation Oncology
AJOU Authors
오, 영택노, 오규전, 미선박, 경주박, 광주김, 미화박, 혜진
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