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Pain relief by Cyberknife radiosurgery for spinal metastasis

Authors
Lee, S; Chun, M
Citation
Tumori, 98(2):238-242, 2012
Journal Title
Tumori
ISSN
0300-89162038-2529
Abstract
AIMS AND BACKGROUND: To report pain relief effect in patients with spinal metastases treated with Cyberknife® and to analyze the factors associated with pain relapse after initial pain relief.



METHODS AND STUDY DESIGN: We retrospectively analyzed patients with spinal metastasis treated with stereotactic body radiosurgery between April 2007 and June 2009. A total of 57 patients with 73 lesions were available for analysis with a median follow-up of 6.8 months (range, 1-30). Pain was assessed by a verbal/visual analogue scale at each visit: from 0 to 10. Pain relief was defined as a decrease of at least three levels of the pain score without an increase in analgesic use. Complete relief was defined as no analgesics or a score 0 or 1.



RESULTS: Pain relief was achieved in 88% of the lesions, with complete relief in 51% within 7 days from the start of radiosurgery. The median duration of pain relief was 3.2 months (range, 1-30). Pain reappeared in 16 patients (27%). Spinal cord compression (P = 0.001) and performance status (P = 0.01) were predictive of pain relapse by multivariate Cox analysis. All 6 patients treated with solitary spinal metastasis experienced pain relief; 5 of them were alive without evidence of disease at a median of 16 months (range, 7-30).



CONCLUSIONS: As previous studies have shown, our study confirms that pain relief with spinal radiosurgery is around 90%. In particular, long-term pain relief and disease control was observed in patients with solitary spinal metastasis.
MeSH terms
AdultAgedFemaleFollow-Up StudiesFractures, Spontaneous/complications/etiologyHumansMaleMiddle AgedMultivariate AnalysisOdds RatioPain/*etiology/*surgeryPain Management/*methodsPain MeasurementProportional Hazards Models*Radiosurgery/instrumentationRecurrenceRetrospective StudiesSpinal Cord Compression/*complications/etiologySpinal Neoplasms/*complications/*secondaryTime FactorsTreatment Outcome
DOI
10.1700/1088.11936
PMID
22677991
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Radiation Oncology
AJOU Authors
전, 미선
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