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Resting cerebral glucose metabolism and perfusion patterns in women with posttraumatic stress disorder related to sexual assault

Authors
Kim, SY; Chung, YK; Kim, BS; Lee, SJ; Yoon, JK; An, YS
Citation
Psychiatry research, 201(3):214-217, 2012
Journal Title
Psychiatry research
ISSN
0165-17811872-7123
Abstract
In the literature, numerous trials using neuroimaging techniques have investigated brain function in patients with post-traumatic stress disorder (PTSD). However, the contrasting results showed that improvements, including in the study design, were required to reach consistent and convincing conclusions. This study evaluated the functional neuroimaging pattern of resting cerebral blood flow and glucose metabolism in patients with PTSD related to sexual assault. Twelve patients were enrolled for both brain single photon emission computed tomography (SPECT) and (18)F-fluorodeoxyglucose positron emission tomography (PET) investigations. All data were analyzed with statistical parametric mapping 2 (SPM2). The PTSD patients showed significant relative decreases in perfusion in the left hippocampus and in the basal ganglia compared with the control group. The PTSD group also had significantly lower cerebral glucosemetabolic activity in the left hippocampus and the superior temporal and precentral gyri than in the control group. These specific patterns of perfusion and glucose metabolism may be closely related to various neurophysiologic symptoms of PTSD.
MeSH terms
AdultBrain MappingCerebral Cortex/*blood supply/*radionuclide imagingFemaleFluorodeoxyglucose F18/metabolismHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMiddle AgedOxytocin/bloodPerfusionPositron-Emission TomographyRest/*physiologySex Offenses/*psychology*Stress Disorders, Post-Traumatic/etiology/pathology/radionuclide imagingTomography, Emission-Computed, Single-Photon
DOI
10.1016/j.pscychresns.2011.08.007
PMID
22464826
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Psychiatry & Behavioural Sciences
Journal Papers > School of Medicine / Graduate School of Medicine > Nuclear Medicine & Molecular Imaging
AJOU Authors
정, 영기이, 수진윤, 준기안, 영실
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