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An injectable biodegradable temperature-responsive gel with an adjustable persistence window

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dc.contributor.authorKim, JI-
dc.contributor.authorKim, da Y-
dc.contributor.authorKwon, DY-
dc.contributor.authorKang, HJ-
dc.contributor.authorKim, JH-
dc.contributor.authorMin, BH-
dc.contributor.authorKim, MS-
dc.date.accessioned2013-05-02T06:35:50Z-
dc.date.available2013-05-02T06:35:50Z-
dc.date.issued2012-
dc.identifier.issn0142-9612-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/8172-
dc.description.abstractɛ-Caprolactone (CL) and 3-benzyloxymethyl-6-methyl-1,4-dioxane-2,5-dion (fLA), with a benzyloxymethyl group at the 3-position of the lactide, were randomly copolymerized. The methoxy polyethylene glycol (MPEG)-b-[poly(ɛ-caprolactone)-ran-poly(3-benzyloxymethyl lactide) (PCL-ran-PfLA)] diblock copolymers were designed such that the PfLA content (0-15 mol%) in the PCL segment was varied. The MPEG-b-(PCL-ran-PfLA) diblock copolymers were derivatized by introducing a pendant benzyl group (MC(x)L(y)-OBn), hydroxyl group (MC(x)L(y)-OH), or carboxylic acid group (MC(x)L(y)-COOH) at the PfLA segment. The derivatized MPEG-b-(PCL-ran-PfLA) diblock copolymer solutions exhibited sol-to-gel phase transitions upon a temperature increase. The sol-to-gel phase transition depended on both the type of functional pendant group on the PfLA and the PfLA content in the PCL segment. MC(x)L(y)-COOH diblock copolymer solutions formed gels immediately after injection into Fischer rats. The gels gradually degraded over a period of 0-6 weeks after the initial injection, and the rate of degradation increased for higher concentrations of PfLA. Immunohistochemical characterization showed that the in vivo MPEG-b-(PCL-ran-PfLA) diblock copolymer gels provoked only a modest inflammatory response. These results show that the MPEG-b-(PCL-ran-PfLA) diblock copolymer gel described here may serve as a minimally invasive therapeutic, in situ-forming gel system with an adjustable temperature-responsive and in vivo biodegradable window.-
dc.language.isoen-
dc.subject.MESHAnimals-
dc.subject.MESHBiocompatible Materials-
dc.subject.MESHBiodegradation, Environmental-
dc.subject.MESHCell Count-
dc.subject.MESHChromatography, Gel-
dc.subject.MESHCrystallization-
dc.subject.MESHDioxanes-
dc.subject.MESHFluorescent Antibody Technique-
dc.subject.MESHGels-
dc.subject.MESHImplants, Experimental-
dc.subject.MESHInjections-
dc.subject.MESHMagnetic Resonance Spectroscopy-
dc.subject.MESHMaterials Testing-
dc.subject.MESHPhase Transition-
dc.subject.MESHPolyesters-
dc.subject.MESHPolyethylene Glycols-
dc.subject.MESHRats-
dc.subject.MESHRats, Inbred F344-
dc.subject.MESHSolutions-
dc.subject.MESHTemperature-
dc.subject.MESHViscosity-
dc.titleAn injectable biodegradable temperature-responsive gel with an adjustable persistence window-
dc.typeArticle-
dc.identifier.pmid22261098-
dc.identifier.urlhttp://linkinghub.elsevier.com/retrieve/pii/S0142-9612(12)00007-5-
dc.contributor.affiliatedAuthor민, 병현-
dc.type.localJournal Papers-
dc.identifier.doi10.1016/j.biomaterials.2012.01.004-
dc.citation.titleBiomaterials-
dc.citation.volume33-
dc.citation.number10-
dc.citation.date2012-
dc.citation.startPage2823-
dc.citation.endPage2834-
dc.identifier.bibliographicCitationBiomaterials, 33(10). : 2823-2834, 2012-
dc.identifier.eissn1878-5905-
dc.relation.journalidJ001429612-
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Journal Papers > School of Medicine / Graduate School of Medicine > Orthopedic Surgery
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