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Combination of high-sensitivity C-reactive protein and homocysteine may predict an increased risk of coronary artery disease in Korean population

Cho, DY; Kim, KN; Kim, KM; Lee, DJ; Kim, BT
Chinese medical journal, 125(4):569-573, 2012
Journal Title
Chinese medical journal
BACKGROUND: The association of emerging biomarkers such as high-sensitivity C-reactive protein (hs-CRP), homocysteine and fibrinogen with the risk of coronary artery disease (CAD) is still uncertain in Asian population including Koreans and little is known about the combined effect of biomarkers on the risk of CAD.

METHODS: A total of 10 650 subjects (6538 men and 4112 women) were enrolled in this study. A 10-year CAD risk was calculated using Framingham risk score modified by the National Cholesterol Education Program (NCEP) Adult Treatment Panel III (ATP III) and levels of circulating hs-CRP, homocysteine and fibrinogen were measured using validated assays.

RESULTS: The 10-year CAD risk gradually augmented with increase in the circulating levels of hs-CRP, homocysteine and fibrinogen. For the highest quartile of hs-CRP, odds ratio (OR) of high-risk for CAD (10-year risk ≥ 20%) compared with the lowest quartile was 3.97 (95%CI: 2.51 - 6.29). For homocysteine and fibrinogen, ORs in the highest quartile compared to the lowest quartile were 5.10 (95%CI: 3.05 - 8.53, P < 0.001) and 1.46 (95%CI: 0.69 - 3.11, P = 0.325), respectively. OR of high-risk for CAD in both the highest quartile of hs-CRP and homocysteine was 9.05 (95%CI: 5.30 - 15.45) compared with the below median of hs-CRP and homocysteine.

CONCLUSIONS: The present study demonstrated that hs-CRP and homocysteine are well associated with the 10-year CAD risk estimated using NCEP ATP III in Koreans and combination of hs-CRP and homocysteine can have strong synergy in predicting the development of CAD.
MeSH terms
AdultAgedAsian Continental Ancestry GroupC-Reactive Protein/*metabolismCoronary Artery Disease/epidemiology/*metabolismFemaleFibrinogen/metabolismHomocysteine/*metabolismHumansMaleMiddle AgedQuestionnairesRisk FactorsYoung Adult
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Journal Papers > School of Medicine / Graduate School of Medicine > Family Practice & Community Health
AJOU Authors
조, 두연김, 규남김, 광민이, 득주김, 범택
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