Cited 0 times in Scipus Cited Count

Increased plasma levels of heat shock protein 70 in patients with vascular mild cognitive impairment.

DC Field Value Language
dc.contributor.authorLee, KS-
dc.contributor.authorChung, JH-
dc.contributor.authorOh, BH-
dc.contributor.authorHong, CH-
dc.date.accessioned2010-12-27T01:49:43Z-
dc.date.available2010-12-27T01:49:43Z-
dc.date.issued2008-
dc.identifier.issn0304-3940-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/819-
dc.description.abstractHeat shock proteins (Hsps) have been regarded as cytoprotectants that protect brain cells from damage encountered following cerebral ischemia or during the progression of neurodegenerative diseases. In this study, we assessed the plasma Hsp70 and Hsp27 levels in not cognitively impaired (NCI) subjects and in patients with mild cognitive impairment (MCI), vascular mild cognitive impairment (VMCI), and probable Alzheimer's disease (AD). Comparison of the plasma Hsp70 and Hsp27 levels of the 4 groups revealed that only the plasma Hsp70 level of VMCI patients (14.11 ng/ml) was significantly higher than that of NCI subjects (11.32 ng/ml), MCI patients (10.16 ng/ml), and patients with probable AD (10.16 ng/ml) after adjustment of age, sex, and education (F=4.231, d.f.=3, p=0.008). Furthermore, there was no difference in plasma Hsp27 levels among the 4 groups. These findings suggest that the plasma Hsp70 level may be related to vascular factors or inflammation.-
dc.language.isoen-
dc.subject.MESHAged-
dc.subject.MESHAlzheimer Disease-
dc.subject.MESHCase-Control Studies-
dc.subject.MESHCognition Disorders-
dc.subject.MESHFemale-
dc.subject.MESHHSP70 Heat-Shock Proteins-
dc.subject.MESHHeat-Shock Proteins-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.titleIncreased plasma levels of heat shock protein 70 in patients with vascular mild cognitive impairment.-
dc.typeArticle-
dc.identifier.pmid18394800-
dc.identifier.urlhttp://linkinghub.elsevier.com/retrieve/pii/S0304-3940(08)00337-6-
dc.contributor.affiliatedAuthor홍, 창형-
dc.type.localJournal Papers-
dc.identifier.doi10.1016/j.neulet.2008.03.025-
dc.citation.titleNeuroscience letters-
dc.citation.volume436-
dc.citation.number2-
dc.citation.date2008-
dc.citation.startPage223-
dc.citation.endPage226-
dc.identifier.bibliographicCitationNeuroscience letters, 436(2). : 223-226, 2008-
dc.identifier.eissn1872-7972-
dc.relation.journalidJ003043940-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Psychiatry & Behavioural Sciences
Files in This Item:
There are no files associated with this item.

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse