163 383

Cited 0 times in

The effect of the ApoE genotype on the association between head circumference and cognition.

Authors
Kim, KR; Lee, KS; Kim, EA; Cheong, HK; Oh, BH; Hong, CH
Citation
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 16(10):819-825, 2008
Journal Title
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
ISSN
1064-74811545-7214
Abstract
OBJECTIVES: The aim of this study was to examine the effect of the ApoE genotype on the association between head circumference (HC) and cognition.



DESIGN: Cross-sectional factorial design in which Korean version of Mini Mental State Examination (K-MMSE) score was the dependent variable with ApoE4 status as one factor and HC as the other.



SETTINGS: A longitudinal cohort study of the Korea Health 21 R&D Project Clinical Research Center for Dementia.



PARTICIPANTS: A total of 1,902 Koreans (599 men and 1303 women) aged over 60 years.



MEASUREMENTS: Cognitive function was assessed by the K-MMSE. HC and ApoE genotyping were carried out on all subjects.



RESULTS: The HC was correlated with the K-MMSE scores (r = 0.22, df = 1,525, p < 0.01), age (r = -0.11, df = 1,521, p < 0.01), educational level (r = 0.30, df = 1,525, p < 0.01), height (r = 0.50, df = 1,384, p < 0.01), and weight (r = 0.49, df = 1,445, p < 0.01). On analysis of covariance, the interaction of ApoE with HC on K-MMSE was observed after adjusting for the age, sex, educational level, height, and weight (F = 2.527, df = 4, 1, 364, p = 0.039). A test of simple main effect according to ApoE status showed that, in the ApoE epsilon 4(-) group, the mean of K-MMSE between HC quintile was not different (F = 0.517, df = 4, 1,148, p = 0.723). But in the ApoE epsilon 4(+) group, the mean of K-MMSE between HC quintile was significantly different. (F = 4.163, df = 4, 211, p = 0.003).



CONCLUSION: All these findings suggest the possibility that the presence of ApoE epsilon 4 affects cognitive function only when the brain reserve is low. In other words, these findings support the structural "brain reserve hypothesis," and the effects are more pronounced in genetically predisposed individuals.
MeSH terms
AgedAging/psychologyAlzheimer Disease/geneticsAnalysis of VarianceApolipoprotein E4/genetics*Apolipoproteins E/genetics*Body Mass IndexBrain/anatomy & histology*Brain/growth & developmentCognition/physiology*Educational StatusFactor Analysis, StatisticalFemaleGenotypeHead/anatomy & histology*HumansKoreaMaleMiddle AgedRegression Analysis
DOI
10.1097/JGP.0b013e3181800551
PMID
18827228
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Psychiatry & Behavioural Sciences
AJOU Authors
홍, 창형
Files in This Item:
Full-Text Not Available.txtDownload
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse