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Serum gamma-glutamyltransferase as a risk factor for general cardiovascular disease prediction in Koreans

Authors
Kim, KM; Kim, BT; Lee, DJ; Park, SB; Joo, NS; Kim, KN
Citation
Journal of investigative medicine : the official publication of the American Federation for Clinical Research, 60(8):1199-1203, 2012
Journal Title
Journal of investigative medicine : the official publication of the American Federation for Clinical Research
ISSN
1081-55891708-8267
Abstract
Gamma-glutamyltransferase (GGT) is a novel cardiovascular disease (CVD) risk factor, but its use as an independent factor for general CVD risk prediction remains unclear in general population. This study examined the association between serum GGT concentration and 10-year CVD risk in Koreans.



METHODS: This cross-sectional study was performed on 27,270 Koreans. Besides individual components of 10-year CVD risk, body mass index, fasting blood glucose, liver enzymes, lipid profile, uric acid and high sensitive C-reactive protein data were used. The study subjects were grouped into quartiles according to the levels of GGT. Analyses relating GGT to 10-year CVD risk greater than 20% used multiple confounders-adjusted logistic regression.



RESULTS: Positive correlations were established between log-transformed GGT concentration and 10-year CVD risk (Spearman's rho = 0.51; P < 0.001). Compared to the lowest baseline GGT category, unadjusted odds ratios for 10-year CVD risk greater than 20% were significantly increased from the lowest to the highest GGT quartiles; these results remained significant after adjustments for multiple confounders.



CONCLUSION: Increased GGT concentration is associated with the increase in 10-year CVD risk. Serum GGT may be helpful to predict the future risk of general CVD.
DOI
10.2310/JIM.0b013e3182746752
PMID
23138005
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Family Practice & Community Health
AJOU Authors
김, 광민김, 범택이, 득주박, 샛별주, 남석김, 규남
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