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Bioplex analysis of plasma cytokines in Alzheimer's disease and mild cognitive impairment.

Authors
Lee, KS; Chung, JH; Lee, KH; Shin, MJ; Oh, BH; Hong, CH
Citation
Immunology letters, 121(2):105-109, 2008
Journal Title
Immunology letters
ISSN
0165-24781879-0542
Abstract
Inflammatory mechanisms within the central nervous system contribute to cognitive impairment via cytokine-mediated interactions between neurons and glial cells. Sixty-nine subjects were consecutively recruited from October 2005 to February 2007. Fifteen individuals were excluded from the study and we ultimately enrolled 19 not cognitively impaired subjects, 25 mild cognitive impairment patients, and 10 Alzheimer's disease patients. To examine the inflammatory markers of mild cognitive impairment and Alzheimer's disease, we measured the plasma concentrations of 23 cytokines using a bioplex assay. The results showed that the macrophage migration inhibitory factor was higher in mild cognitive impairment and in Alzheimer's disease patients compared with the not cognitively impaired group; the results also showed that monokine induced by gamma interferon was higher in Alzheimer's disease patients than in not cognitively impaired subjects, as well as those of the mild cognitive impairment group.
MeSH terms
AgedAged, 80 and overAlzheimer Disease/bloodAlzheimer Disease/diagnosisAlzheimer Disease/immunology*Alzheimer Disease/psychologyBiological Markers/bloodChemokine CXCL9/blood*Chemokine CXCL9/geneticsChemokine CXCL9/immunologyCognition Disorders/bloodCognition Disorders/diagnosisCognition Disorders/immunology*Cognition Disorders/psychologyCytokines/blood*Cytokines/geneticsCytokines/immunologyDisease ProgressionEnzyme-Linked Immunosorbent AssayFemaleGene Expression Regulation/immunologyHumansIntramolecular Oxidoreductases/blood*Intramolecular Oxidoreductases/geneticsIntramolecular Oxidoreductases/immunologyMacrophage Migration-Inhibitory Factors/blood*Macrophage Migration-Inhibitory Factors/geneticsMacrophage Migration-Inhibitory Factors/immunologyMalePolymersPrognosis
DOI
10.1016/j.imlet.2008.09.004
PMID
18930766
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Psychiatry & Behavioural Sciences
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홍, 창형
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