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Methyl-beta-cyclodextrin, a specific cholesterol-binding agent, inhibits melanogenesis in human melanocytes through activation of ERK.

Authors
Jin, SH; Lee, YY; Kang, HY
Citation
Archives of dermatological research, 300(8):451-454, 2008
Journal Title
Archives of dermatological research
ISSN
0340-36961432-069X
Abstract
Cholesterol has been suggested to regulate cell differentiation. In this study, we have examined the effects of cholesterol modulation on pigmentation of skin using a treatment with methyl-beta-cyclodextrin (MbetaCD), a specific cholesterol-binding agent. Treatment with MbetaCD reduced pigmentation in human melanocyte and cultured skin. This decrease in pigmentation was related to the inhibition of the expression of tyrosinase and microphthalmia-associated transcription factor of melanocytes. Stimulation of melanocytes with MbetaCD led to the time-dependent phosphorylation of extracellular signal-regulated kinase (ERK). Furthermore, ERK functionally regulated the MbetaCD-induced melanin formation in melanocytes; a ERK inhibitor, PD98059, almost completely attenuated the MbetaCD-mediated inhibition of melanin synthesis and down-regulation of MITF and tyrosinase expression. These results suggest that cholesterol reduction by MbetaCD inhibit melanin synthesis via ERK activation and subsequent MITF downregulation.
MeSH terms
Cells, CulturedCholesterol/metabolism*Extracellular Signal-Regulated MAP Kinases/physiology*Flavonoids/pharmacologyHumansMelanins/biosynthesis*Melanocytes/drug effects*Melanocytes/metabolismMicrophthalmia-Associated Transcription Factor/analysisOrgan Culture TechniquesPeptides/pharmacologySkin Pigmentation/drug effectsbeta-Cyclodextrins/pharmacology*
DOI
10.1007/s00403-008-0864-z
PMID
18478239
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Dermatology
AJOU Authors
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