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Effects of methamphetamine on single unit activity in rat medial prefrontal cortex in vivo

Authors
Jang, JW; Ha, HJ; Kim, YB; Chung, YK; Jung, MW
Citation
Neural plasticity, 2007:29821-29821, 2007
Journal Title
Neural plasticity
ISSN
2090-59041687-5443
Abstract
To investigate how neuronal activity in the prefrontal cortex changes in an animal model of schizophrenia, we recorded single unit activity in the medial prefrontal cortex of urethane-anesthetized and awake rats following methamphetamine (MA) administration. Systemic MA injection (4 mg/kg, IP) induced inconsistent changes, that is, both enhancement and reduction, in unit discharge rate, with a subset of neurons transiently (< 30min) elevating their activities. The direction of firing rate change was poorly predicted by the mean firing rate or the degree of burst firing during the baseline period. Also, simultaneously recorded units showed opposite directions of firing rate change, indicating that recording location is a poor predictor of the direction of firing rate change. These results raise the possibility that systemic MA injection induces random bidirectional changes in prefrontal cortical unit activity, which may underlie some of MA-induced psychotic symptoms.
Keywords
dopaminedopamine uptake inhibitormethamphetamineanimal modelanimal tissuearticlecell activitycontrolled studyin vivo studymalenerve cell plasticitynerve conductionnonhumanpredictionprefrontal cortexratrefractory periodschizophreniasedationtemporal summationwakefulnessaction potentialanimalchemically induced disorderdisease modeldrug effecthistologymetabolismnerve cellpathophysiologyphysiologypsychosisSprague Dawley ratstatisticssynaptic transmission
Appears in Collections:
Journal Papers > Research Organization > Institute for Medical Sciences
Journal Papers > School of Medicine / Graduate School of Medicine > Psychiatry & Behavioural Sciences
AJOU Authors
정, 영기정, 민환
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