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Predicted Effect-site Concentration of Remifentanil for Facilitating Laryngeal Mask Airway Insertion with Propofol Target-Controlled Infusion

Other Title
Propofol 목표농도조절주입 시 후두마스크 삽입에 필요한 Remifentanil의 예상 효과처농도
Authors
김, 종엽; 박, 성용; 문, 봉기; 김, 진수
Citation
Taehan Mach'ikwa Hakhoe chi, 52(4):381-385, 2007
Journal Title
Taehan Mach'ikwa Hakhoe chi; The Journal of the Korean Society of Anesthesiologists; 대한마취과학회지
ISSN
0302-5780
Abstract
Background: The addition of remifentanil during the propofol induced anesthesia facilitates the insertion of laryngeal mask airway (LMA) with minimal adverse hemodynamic disturbances. This study predicted the optimal effect-site concentration of remifentanil for LMA insertion with propofol target-controlled infusion (TCI).



Methods: In 25 adults patients, aged 18?60 years, anesthesia was induced with propofol TCI at the effect-site concentration of 4μg/ml. Two minutes later, the predetermined effect-site concentration of remifentanil was started. The remifentanil concentration was determined using modified Dixon’s up-and-down method (0.5 ng/ml as a step size). The first patient was tested at 2.0 ng/ml remifentanil. The insertion of LMA was attempted 3 min after remifentanil TCI began. The response of the patients to the insertion of LMA was classified as either ’movement’ or ’no movement’.



Results: The remifentanil concentration at which there was a 50% probability of successful LMA insertion (EC50) was 3.18 ? 0.53 ng/ml. From probit analysis, the EC50 of remifentanil was 3.10 ng/ml (95% confidence limits, 2.55?4.11 ng/ml), and the EC95 was 4.31 ng/ml (95% confidence limits, 3.64?11.11 ng/ml).



Conclusions: The predicted effect-site concentration of remifentanil for facilitating LMA insertion was 3.18 ng/ml in 50% of adults during propofol TCI at an effect-site concentration of 4μg/ml without premedication.
Keywords
effect-sitelaryngeal mask airwaypropofolremifentanil
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Anesthesiology & Pain Medicine
AJOU Authors
김, 종엽박, 성용문, 봉기김, 진수
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