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Salvage liver transplantation for recurrent hepatocellular carcinoma after liver resection: feasibility of the Milan criteria and operative risk.

Authors
Kim, BW; Park, YK; Kim, YB; Wang, HJ; Kim, MW
Citation
Transplantation proceedings, 40(10):3558-3561, 2008
Journal Title
Transplantation proceedings
ISSN
0041-13451873-2623
Abstract
INTRODUCTION: Although the Milan criteria are widely accepted for liver transplantation (OLT) for hepatocellular carcinoma (HCC), they have not been fully evaluated as feasible for salvage liver transplantation (SLT) of recurrent HCC after hepatic resection. The operative difficulties of SLT increase the operative risk. The aim of this study was to evaluate the feasibility of the Milan criteria for SLT and its operative complications.



PATIENTS AND METHODS: From March 2005 to November 2007, 46 HCC patients received OLT including 15 SLTs after prior partial hepatectomy (SLT group) and 31 primary OLTs (PLT group).



RESULTS: There was no postsurgical hospital mortality among the SLT group but one case in the PLT group due to pneumonia followed by sepsis. There was no difference in the incidence of surgical complications between the two groups. Overall survival rates of SLT group patients were similar to those of the PLT group (P = .14), especially comparing both groups of patients within the Milan criteria (P = .89). There was no recurrence of HCC among the patients within the Milan criteria.



CONCLUSIONS: SLT is a feasible procedure for recurrent HCC meeting the Milan criteria; the operative risk of the SLT is also acceptable.
MeSH terms
AdultCarcinoma, Hepatocellular/surgery*Feasibility StudiesFemaleHumansLiver Neoplasms/surgery*Liver Transplantation/adverse effectsLiver Transplantation/methods*MaleMiddle AgedNeoplasm Recurrence, Local/surgery*Patient SelectionPostoperative Complications/epidemiologyRetrospective StudiesRisk FactorsSalvage Therapy/methods
DOI
10.1016/j.transproceed.2008.03.175
PMID
19100437
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Surgery
Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
AJOU Authors
김, 봉완김, 영배왕, 희정김, 명욱
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