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Clinical Features and Signficance of in Vitro Testing of 16 Cases of Amoxicillin-Induced Hypersensitivity Reactions

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dc.contributor.author박, 한정-
dc.contributor.author허, 규영-
dc.contributor.author김, 현아-
dc.contributor.author최, 길순-
dc.contributor.author최, 성진-
dc.contributor.author박, 해심-
dc.description.abstractBackground: Amoxicillin is one of the broad spectrum antibiotics and is widely used in the treatment of various infective diseases. There are various forms of amoxicillin- induced hypersensitivity reactions including urticaria/angioedema, erythema multiforme and anaphylaxis.

Objective: To observe the clinical features and evaluate the significance of in vitro testing of amoxicilin-induced hypersensitivity reactions.

Method: We retrospectively reviewed medical records of patients diagnosed as having amoxicillin-induced hypersensitivity reactions from January 2002 to February 2007. Serum-specifc IgE antiboides to ampicilloyl (AMP) and amoxicilloyl (AXO) were determined using the immunoCAP system.

Result: Sixteen subjects were enrolled in this study. Clinical features of amoxicillin-induced hypersensitivity reactions included erythema multiforme (n=6, 37.5%), urticaria/angioedema (n=4, 25.0%), anaphylaxis (n=3, 18.8%), maculopapular skin eruption (n=2, 12.5%) and fixed-drug eruptions (n=1, 6.3%). Six subjects had a high serum specific IgE to AMP and all anaphylaxis patients had a high serum specific IgE to AXO and/or AMP.

Conclusion: These findings suggest that amoxicillin could induce various cutaneous manifestations in which the most common ones are erythema multiforme and urticaria/ angioedema. The serious reactions of anaphylaxis were noted in 18.8% of subjects in which IgE mediated responses to 2 antigenic determinants were involved.
dc.titleClinical Features and Signficance of in Vitro Testing of 16 Cases of Amoxicillin-Induced Hypersensitivity Reactions-
dc.title.alternative아목시실린에 의한 약물 과민반응 16예의 임상적 특성과 혈청학적 검사의 의의-
dc.subject.keywordDrug allergy-
dc.subject.keywordHypersensitivity response-
dc.contributor.affiliatedAuthor허, 규영-
dc.contributor.affiliatedAuthor김, 현아-
dc.contributor.affiliatedAuthor최, 성진-
dc.contributor.affiliatedAuthor박, 해심-
dc.type.localJournal Papers-
dc.citation.titleChʿŏnsik mit alrerugi-
dc.citation.titleJournal of asthma, allergy and clinical immunology-
dc.citation.titleKorean journal of asthma, allergy and clinical immunology-
dc.citation.title천식 및 알레르기-
dc.identifier.bibliographicCitationChʿŏnsik mit alrerugi, 27(3):162-167, 2007-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Rheumatology
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
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