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Cadmium-induced E-cadherin Expression in Cerebrovascular Endothelial Cells

DC Field Value Language
dc.contributor.author석, 선미-
dc.contributor.author이, 태구-
dc.contributor.author김, 영채-
dc.contributor.author문, 창현-
dc.contributor.author백, 은주-
dc.contributor.author정, 이숙-
dc.contributor.author이, 수환-
dc.date.accessioned2014-01-02T03:51:49Z-
dc.date.available2014-01-02T03:51:49Z-
dc.date.issued2007-
dc.identifier.issn1226-9158-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/8757-
dc.description.abstractThe effect of cadmium chloride on the expression of E-cadherin was examined in bEnd.3 mouse brain endothelial cells. induced release, which were blocked by non-steroidal antinflamatory drugs (NSAIDs) such as indomethacin and NS398 indicating the expression of COX-2 might contribute to production. decreased the expression of E-cadherin, but not VE-cadherin at levels of mRNA and protein. Reduced expression level of E-cadherin was restored by NSAIDs, which was reversed by the addition of . -induced decrease of E-cadherin level was also recovered by antioxidants including N-acetylcyteine (NAC) and trolox. Together with previous report which showed induced COX-2 expression in a cellular oxidative stress dependent manner, these data suggest that decreases E-cadherin expression through induction of cellular oxidative stress and in turn COX-2 expression in brain endothelial cells.-
dc.language.isoko-
dc.titleCadmium-induced E-cadherin Expression in Cerebrovascular Endothelial Cells-
dc.title.alternative카드뮴이 뇌혈관 내피세포에서의 E-cadherin 발현에 미치는 영향-
dc.typeArticle-
dc.identifier.urlhttps://www.e-eht.org/upload/pdf/eht-22-2-137.pdf-
dc.subject.keywordcadmium-
dc.subject.keywordbrain endothelial cell-
dc.subject.keywordE-cadherin-
dc.subject.keywordoxidative stress-
dc.subject.keywordcyclooxygenase-2-
dc.contributor.affiliatedAuthor문, 창현-
dc.contributor.affiliatedAuthor백, 은주-
dc.contributor.affiliatedAuthor정, 이숙-
dc.contributor.affiliatedAuthor이, 수환-
dc.type.localJournal Papers-
dc.citation.titleJournal of environmental toxicology-
dc.citation.volume22-
dc.citation.number2-
dc.citation.date2007-
dc.citation.startPage137-
dc.citation.endPage145-
dc.identifier.bibliographicCitationJournal of environmental toxicology, 22(2). : 137-145, 2007-
dc.relation.journalidJ112269158-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Physiology
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