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Age-and region-dependent changes in three-dimensional microstructural properties of proximal femoral trabeculae.
DC Field | Value | Language |
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dc.contributor.author | Cui, WQ | - |
dc.contributor.author | Won, YY | - |
dc.contributor.author | Baek, MH | - |
dc.contributor.author | Lee, DH | - |
dc.contributor.author | Chung, YS | - |
dc.contributor.author | Hur, JH | - |
dc.contributor.author | Ma, YZ | - |
dc.date.accessioned | 2010-12-28T06:49:37Z | - |
dc.date.available | 2010-12-28T06:49:37Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0937-941X | - |
dc.identifier.uri | http://repository.ajou.ac.kr/handle/201003/876 | - |
dc.description.abstract | This study investigated regional variations in the 3D microstructure of trabecular bone in human proximal femur, with respect to aging. The results demonstrate that age-related changes in trabecular microstructure significantly varied from different sub-regions of the proximal femur.
INTRODUCTION: We hypothesize that the age-related changes in trabecular bone microstructure appear to be varied from specific anatomic sub-regions of the proximal femur followed by non-uniform bone loss. The purpose of this study was therefore to explore regional variations in the 3D microstructure of trabecular bone in human proximal femur, with respect to aging. METHODS: A total of 162 trabecular bone cores from six regions of 27 femora of male cadaver donors were scanned using micro-computed tomography (micro-CT). The following microstructural parameters were calculated: bone volume fraction (BV/TV), trabecular number (Tb.N), thickness (Tb.Th) and separation (Tb.Sp), structure model index (SMI), and degree of anisotropy (DOA). RESULTS: Age-related changes in trabecular microstructure varied from different regions of the proximal femur. There was a significant decrease in bone volume fraction and an almost identical decrease in trabecular thickness associated with aging at any region. Regional analysis demonstrated a significant difference in BV/TV, Tb.Th, Tb.Sp, Tb.N and DOA between superior and inferior neck, as well as a significant difference in BV/TV, Tb.Sp, Tb.N, SMI and DOA between superior and inferior trochanter. CONCLUSIONS: Age-related changes in bone loss and trabecular microstructure within the male proximal femur are not uniform in this cadaveric population. | - |
dc.language.iso | en | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Aging | - |
dc.subject.MESH | Anisotropy | - |
dc.subject.MESH | Femur | - |
dc.subject.MESH | Femur Head | - |
dc.subject.MESH | Femur Neck | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Imaging, Three-Dimensional | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | X-Ray Microtomography | - |
dc.title | Age-and region-dependent changes in three-dimensional microstructural properties of proximal femoral trabeculae. | - |
dc.type | Article | - |
dc.identifier.pmid | 18437273 | - |
dc.contributor.affiliatedAuthor | 원, 예연 | - |
dc.contributor.affiliatedAuthor | 정, 윤석 | - |
dc.type.local | Journal Papers | - |
dc.identifier.doi | 10.1007/s00198-008-0601-7 | - |
dc.citation.title | Osteoporosis international | - |
dc.citation.volume | 19 | - |
dc.citation.number | 11 | - |
dc.citation.date | 2008 | - |
dc.citation.startPage | 1579 | - |
dc.citation.endPage | 1587 | - |
dc.identifier.bibliographicCitation | Osteoporosis international, 19(11). : 1579-1587, 2008 | - |
dc.identifier.eissn | 1433-2965 | - |
dc.relation.journalid | J00937941X | - |
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