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The Clinical Significance of Transforming Growth Factor (TGF) β1, TGFβ ReceptorβII, p53 Protein and K-ras Point Mutation in Pancreatic Cancer

Other Title
췌장암에서의 Transforming Growth Factor (TGF)β1, TGFβ Receptor II, p53 단백질 및 K-ras 돌연변이 유전자의 임상적 의의
Authors
김, 구상; 채, 영수; 김, 정택
Citation
Taehan Oekwa Hakhoe, 74(4):274-281, 2008
Journal Title
Taehan Oekwa Hakhoe; 대한외과학회지
ISSN
1226-0053
Abstract
Purpose: Many cancers, including pancreatic cancer, harbor defects in TGF? signaling and are resistant to TGF? mediated growth inhibition. In addition, the expression of the p53 gene and mutations in K-ras might play an important role in the multistep carcinogenesis of pancreatic cancer. This study examined the expression level of TGF?1, TGF? receptorII (T?RII), p53 protein and K-ras mutation in pancreatic cancer, along with their role and clinical significance.



Methods: The overexpression of TGF?1, T?RII and p53 protein was evaluated using an immunohistochemical assay. The K-ras mutation was analyzed by PCR-RFLP in the surgical resected pancreatic tissue from 26 pancreatic ductal adenocarcinomas and 5 normal pancreases.



Results: Immunohistochemical analysis of TGF?1 and T?RII revealed positive immunostaining in 73.1% and 76.9% of the tumors, respectively, which were significantly higher than the normal pancreas (P=0.008). The p53 protein was positive in none of the 5 normal ducts and 16 out of 26 (61.5%) pancreatic carcinoma specimens. The K-ras mutation was positive in none of the 5 normal ducts, and in 20 of the 26 pancreatic carcinoma specimens (76.9%). The presence of TGF?1 and T?RII in the cancer samples was significantly associated with node metastasis, advanced tumor stage (P<0.01), and a short survival time (P<0.05). The p53-positive pancreatic cancers showed a significantly lower survival rate than those with p53-negative tumors (P< 0.05). There was no correlation between K-ras mutations and the survival rates.



Conclusion: The detection of K-ras mutations and TGF?1, T?RII and p53 protein overexpression can predict the prognosis of pancreatic carcinoma patients.
Keywords
Pancreatic cancerTransforming growth factorβ1Transforming growth factor β receptor IIp53 proteinK-ras mutation
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Surgery
AJOU Authors
김, 구상
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