Expression of Macrophage Migration Inhibitory Factor in Behcet`s Disease
베체트병에서 MIF 발현에 대한 연구
인, 성일; 백, 진아; 박, 경숙; 방, 동식; 이, 은소
Korean journal of dermatology, 46(5):611-618, 2008
Korean journal of dermatology; 대한피부과학회지
Background: Macrophage migration inhibitory factor (MIF) is a unique protein, participating in inflammation,
immune response, and cell growth. Previous reports showed that MIF-polymorphisms are associated with an
increased risk for various inflammatory diseases.
Objective: This study was designed to investigate the effect of MIF polymorphisms on Behcet’s disease (BD).
Methods: A total of 362 patients with BD and 290 healthy controls were genotyped. We also performed RT-PCR
analysis, ELISA, and immunohistochemical stain for MIF.
Results: We could not find statistically significant differences in the genotype frequencies of the MIF-794[CATT]5-8 repeat polymorphism or MIF-173 G＞C polymorphism between BD patients and controls. Immunohistochemical
analysis showed that MIF protein was diffusely distributed throughout epidermis and subcutaneous fat tissue from
the skin lesions of patients with BD and erythema nodosum.
Conclusion: Contrary to earlier reports, serum MIF levels were decreased in patients with BD, and the prescence
of polymorphisms in the MIF promoter region was not associated with disease susceptibility. Nevertheless, MIF may play a role in cutaneous inflammation in BD.
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