Cited 0 times in Scipus Cited Count

The first neurosurgical analysis of 8 korean children with sotos syndrome.

DC Field Value Language
dc.contributor.authorLim, JJ-
dc.contributor.authorYoon, SH-
dc.date.accessioned2010-12-29T04:32:59Z-
dc.date.available2010-12-29T04:32:59Z-
dc.date.issued2008-
dc.identifier.issn2005-3711-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/893-
dc.description.abstractOBJECTIVE: Sotos Syndrome is characterized by macrocephaly, overgrowth, and developmental delay, and more than 300 patients have been reported worldwide to date. The authors reviewed the clinical characteristics of 8 patients with Sotos Syndrome in Korea for a new understanding and treatment strategies.
METHODS: The medical records of a total of eight Korean children with Sotos Syndrome were reviewed. All patients underwent developmental checkup, lumbar punctures for measurement of intracranial pressure (ICP), brain and spine magnetic resonance imaging and computerized tomography.
RESULTS: All 8 patients showed macrocephaly and the characteristic craniofacial features of Sotos Syndrome. Other clinical characteristics shown were overgrowth (7/8), developmental delay (7/8), congenital heart defect (3/8), flat foot (8/8), scoliosis (4/8), spina bifida (8/8), hydrocephalus (4/8), cavum vergae (3/8), and increased subdural fluid collection (5/8). Mean ICP measured via lumbar puncture was 27.35+/-6.25 cm H(2)O (range 20 to 36 cm H(2)O). Two patients received ventriculo-peritoneal shunt, and 1 patient underwent subduro-peritoneal shunt with improvement. Spinal orthosis was applied to 4/5 patients with scoliosis and 4/8 children with flat foot were provided with foot orthosis.
CONCLUSION: In this first Korean study of 8 Sotos Syndrome patients we demonstrated the presence of spina bifida and increased ICP, which had not been previously described. The authors therefore suggest that all patients with Sotos Syndrome should undergo examination for the presence of spina bifida, and that shunt procedures would improve development and alleviate clinical symptoms.
en
dc.formattext/plain-
dc.language.isoen-
dc.titleThe first neurosurgical analysis of 8 korean children with sotos syndrome.-
dc.typeArticle-
dc.identifier.pmid19096684-
dc.identifier.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2588310/-
dc.subject.keywordSotos Syndrome-
dc.subject.keywordSpina bifida-
dc.subject.keywordIntracranial pressure-
dc.subject.keywordHydrocephalus-
dc.subject.keywordShunt-
dc.contributor.affiliatedAuthor윤, 수한-
dc.type.localJournal Papers-
dc.identifier.doi10.3340/jkns.2008.44.4.240-
dc.citation.titleJournal of Korean Neurosurgical Society-
dc.citation.volume44-
dc.citation.number4-
dc.citation.date2008-
dc.citation.startPage240-
dc.citation.endPage244-
dc.identifier.bibliographicCitationJournal of Korean Neurosurgical Society, 44(4). : 240-244, 2008-
dc.identifier.eissn1598-7876-
dc.relation.journalidJ020053711-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Neurosurgery
Files in This Item:
19096684.pdfDownload

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse