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CLINICAL STUDY OF BISPHOSPHONATE-INDUCED OSTEONECROSIS OF MANDIBULAR AND MAXILLARY BONE

Other Title
비스포스포네이트로 인한 하악 및 상악골에 발생한 골괴사에 대한 임상적 연구
Authors
정, 혜린; 김, 태완; 이, 정근; 송, 승일
Citation
Taehan Kugang Akanmyŏn Oekwa Hakhoe chi, 35(5):353-360, 2009
Journal Title
Taehan Kugang Akanmyŏn Oekwa Hakhoe chi; The journal of Korean Academy of Oral and Maxillofacial Surgery; 대한구강악안면외과학회지
ISSN
1225-1585
Abstract
Bisphosphonates are compounds widely used in the treatment of various metabolic and malignant bone disease. Recently, an association between bisphosphonate use and a rare dental condition termed 'osteonecrosis of the jaw(ONJ)' has been reported. Bisphosphonate-related osteonecrosis of the jaw(BRONJ) is rare, but serious, side effect of bisphosphonate therapy in affected patients. It is characterized by poor wound healing and spontaneous intra-oral soft tissue break down, which lead to exposure of necrotic maxillary and mandibular bone. We reviewed 11 patients of BRONJ visited Ajou University Hospital Dental clinic from May 2007 to November 2008. The management of the patients included cessation of bisphosphonate therapy and various surgical restorative procedures and conservative care there after. Aggressive debridement is contraindicated. A new complication of bisphosphonate therapy administration, osteonecrosis of jaws, seems to be developing. The improved results after cessation of the medication should make clinicians reconsider the merits of the rampant use of bisphosphonates, while further investigation is needed to completely elucidate this complication.
Keywords
BRONJ (Bisphosphonate-related osteonecrosis of the jaw)OsteonecrosisOsteoporosis
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Dentistry
AJOU Authors
김, 태완이, 정근송, 승일
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