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Exposure and Elevated Serum Total Immunoglobulin E Level are Major Risk Factors of Sensitization to Pancreatic Enzymes among Health Care Workers in a Single Hospital

Other Title
병원 근로자에서 노출과 총 IgE의 증가는 췌장 효소제에 대한 감작의 위험인자이다
김, 상훈; 이, 병훈; 박, 해심; 이, 재형
Chʿŏnsik mit alrerugi, 29(1):21-26, 2009
Journal Title
Chʿŏnsik mit alrerugi; Journal of asthma, allergy and clinical immunology; Korean journal of asthma, allergy and clinical immunology; 천식 및 알레르기
Background: Enzyme powders inhaled at workplace can induce respiratory allergy in health care workers. It is important to elucidate which risk factors contribute to the sensitization of these enzymes in health care workers.

Objective: This study evaluates the prevalence and the risk factors of sensitization to pancreatic enzyme owders in health care workers.

Method: A total of 220 health care workers (199 nurses and 21 pharmacist’s office workers) who were exposed to pancreatic enzyme powders during work and 64 unexposed controls (office workers) in a single hospital were analyzed using a questionnaire, and measurements of total serum IgE level and specific IgE against house dust mite and the most popular pancreatic enzymes (α-amylase and pancreatin).

Result: The overall prevalence of sensitization to pancreatic enzymes was 4.7%. Sensitization to pancreatic nzymes is significantly higher in pharmacist’s office workers (28.6%) than in controls (0%) or nurses (5.0%). In multivariate analysis, occupational exposure (OR, 25.5; 95% CI, 5.7∼113.5), and elevated total IgE level (OR, 6.95; 95% CI, 1.6∼28.9) ere associated with sensitization to pancreatic enzymes.

Conclusion: Occupational exposure and elevated serum IgE level may be important determinants of sensitization to pancreatic enzymes in health care workers. Measures to reduce exposure may be the most effective means to reduce sensitization.
Alpha-amylaseIgEHypersensitivityExposureHealth care worker
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Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
AJOU Authors
박, 해심
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