79 219

Cited 0 times in

Effect of low dose ketamine to prevent remifentanil-induced cough: a randomized, double-blind, placebo controlled trial

Authors
Kim, JY; Park, SY; Jung, WS; Kwak, HJ
Citation
Korean journal of anesthesiology, 56(6):624-627, 2009
Journal Title
Korean journal of anesthesiology
ISSN
2005-64192005-7563
Abstract
Background: A reflex cough is often observed after an intravenous (IV) bolus of remifentanil. Since ketamine was reported to be effective in modulating the cough reflex, this prospective, randomized, double-blind, placebo-controlled study was designed to evaluate the efficacy of pretreatment with ketamine on remifentanil-induced cough.



Methods: 320 patients undergoing general anesthesia for elective surgery were randomly allocated into two groups to receive either IV ketamine 0.1 mg/kg (ketamine group, n = 156) or 0.9% saline (saline group, n = 154) 1 min before administration of remifentanil at a target effect-site concentration of 5 ng/ml. Severity of cough was graded (mild, 1?2; moderate, 3?4; and severe, 5 or >5).



Results: The overall incidence of cough was significantly higher in the saline group (43/154 patients; 0.28, 95% CI 0.21, 0.36) than that in the ketamine group (18/156 patients; 0.12, 95% CI 0.07, 0.18) (P < 0.001). However, there was no significant difference in the severity and the onset time of cough between the groups.



Conslusions: IV ketamine 0.1 mg/kg one minute before remifentanil was effective in suppressing remifentanil-induced cough without affecting the severity and onset time.
Keywords
KetamineOpioid-induced coughRemifentanil
DOI
10.4097/kjae.2009.56.6.624
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Anesthesiology & Pain Medicine
AJOU Authors
김, 종엽박, 성용
Full Text Link
Files in This Item:
624-627.pdfDownload
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse