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The effects of prophylactic dolasetron and induction with propofol on postoperative nausea and vomiting after thyroidectomy

Other Title
예방적으로 투여한 Dolasetron과 마취 유도제로 사용한 Propofol이 갑상선 절제술 후 오심과 구토에 미치는 영향
조, 한범; 박, 은정; 박, 선경; 김, 은진; 박, 재홍; 최, 정웅; 김, 진수; 이, 숙영
Korean journal of anesthesiology, 57(3):320-326, 2009
Journal Title
Korean journal of anesthesiology
Background: Postoperative nausea and vomiting (PONV) is a common problem in patients undergoing thyroidectomy. In this study we evaluated the effects of prophylactic dolasetron and/or induction with propofol on PONV.  

Methods: Two hundred three patients scheduled thyroidectomy under general anesthesia with sevoflurane were included and were randomly allocated to one of four groups. In control (group C) and dolasetron groups (group D), the patients received thiopental sodium 4?5 mg/kg intravenously for the induction of anesthesia, and the patients in group D received prophylactic intravenous dolasetron 210?g/kg. In propofol (group P) and dolasetron + propofol groups (group D + P), the patients received propofol 2 mg/kg intravenously for the induction of anesthesia, and the patients in group D + P received prophylactic intravenous dolasetron 210?g/kg. The incidence and severity of PONV, the need for rescue antiemetics, adverse events were assessed during 0 to 1 hour and 1 to 24 hours postoperatively.  

Results: During the first 24 hours after anesthesia, the incidences of PONV and postoperative vomiting were significantly reduced in group D + P compared with group C (P < 0.05, respectively). There were no significant differences in postoperative nausea, need for rescue antiemetics, severity of PONV, and adverse events of antiemetics among the four groups.  

Conclusions: In patients with thyroidectomy, combination of prophylactic dolasetron administration and induction with propofol was found to reduce the incidence of PONV during the first 24 hours after anesthesia, compared with that of routine induction with thiopental sodium.
DolasetronPostoperative nausea and vomiting (PONV)PropofolThyroidectomy
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Journal Papers > School of Medicine / Graduate School of Medicine > Anesthesiology & Pain Medicine
AJOU Authors
조, 한범박, 은정김, 진수이, 숙영
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