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Genetic studies of allergic disease and their clinical implications

Other Title
알레르기 질환에서 유전체 연구 현황과 임상적 유용성
Authors
김, 승현; 박, 해심
Citation
The Korean journal of medicine, 76(4):416-424, 2009
Journal Title
The Korean journal of medicine; 대한내과학회지
ISSN
1738-93642289-0769
Abstract
Allergic disease is a complex disorder in which the interaction between environmental and genetic effects may modify both the susceptibility to and severity of the disease. Over the last few years, our understanding of the genetic basis of allergic diseases has improved markedly, which has led to the identification of several chromosome regions and loci showing linkage to allergic disease. As another approach, association studies between candidate gene polymorphisms and allergic diseases have been conducted in many areas and replicated in different ethnic groups. These approaches need to be followed by validation processes to confirm their functional relevance in the pathophysiology of allergic disease. This review updates genetic studies of and recent findings in, allergic disease.
Keywords
천식약물이상반응유전체 연구Allergic diseaseGenetic studyPositional cloningAssociation study
Appears in Collections:
Journal Papers > Research Organization > Regional Clinical Trial Center
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
AJOU Authors
김, 승현박, 해심
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