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Prevalence of Subclinical Hypothyroidism in Two Population Based-cohort: Ansung and KLoSHA Cohort in Korea

Other Title
지역사회 코호트 연구를 통한 한국인에서 무증상 갑상선 기능저하증의 유병률 분석
Authors
최, 훈성; 박, 영주; 김, 현규; 임, 수; 박, 도준; 장, 학철; 조, 남한; 조, 보연
Citation
Journal of Korean Thyroid Association, 3(1):32-40, 2009
Journal Title
Journal of Korean Thyroid Association; 대한갑상선학회지
ISSN
2005-162X
Abstract
Background and Objectives :We examined the prevalence of subclinical hypothyroidism (SCH) in Korean population.



Materials and Methods : Using data from two cohorts, Ansung cohort consist of adults between 40 and 70 years old and Korean Longitudinal Study on Health and Aging (KLoSHA) study consist of elderly subjects over 65 years old, we examined the prevalence of SCH and the association of age with SCH, free T4 and thyrotropin (TSH).



Results:The prevalence of SCH was 11.7% in Ansung cohort and 17.3% in KoSHA study. The prevalence of SCH increased with advanced age in Ansung cohort, especially in the male subjects. In the male subjects of Ansung cohort, serum free T4 decreased and TSH increased with advanced age, whereas age was not associated with free T4 and TSH concentration in the female subjects. In KLoSHA study, age did not show significant association with prevalence of SCH and concentrations of free T4 and TSH. Anti- thyroidperoxidase (TPO) antibody was associated with SCH, however, it did not show significant association with advanced age in both cohorts.



Conclusion: In Korean population, the prevalence of SCH was 11.7% in adults and 17.3% in elderly subjects. The prevalence of SCH increased with advanced age, however, it did not increase any more in elderly subjects.
Keywords
무증상 갑상선 기능저하증유병률지역 사회Subclinical hypothyroidismPrevalenceKorean population
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Preventive Medicine & Public Health
AJOU Authors
조, 남한
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