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Clinical Efficacy and Tolerance of 1% Nadifloxacin Cream in the Treatment of Mild to Moderate Acne Vulgaris in South Korea

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dc.contributor.author최, 원준-
dc.contributor.author김, 광중-
dc.contributor.author김, 낙인-
dc.contributor.author계, 영철-
dc.contributor.author서, 대헌-
dc.contributor.author이, 주흥-
dc.contributor.author김, 명남-
dc.contributor.author이, 은소-
dc.contributor.author이, 주희-
dc.contributor.author노, 영석-
dc.date.accessioned2014-02-13T06:37:43Z-
dc.date.available2014-02-13T06:37:43Z-
dc.date.issued2010-
dc.identifier.issn0494-4739-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/9319-
dc.description.abstractBackground: Antimicrobials have been a mainstay of inflammatory acne treatment for more than 30 years. However, antibiotic-resistant propionibacteria had been isolated with increased frequency, and associated with failure to respond to antibiotic therapy.



Objective: The aim of this study was to investigate the clinical efficacy and tolerance of 1% nadifloxacin cream.



Methods: In the final analysis, 197 patients with mild to moderate facial acne vulgaris were enrolled. The patients were instructed to apply 1% nadifloxacin cream twice daily to the affected skin after washing the face. Following 2 and 4 weeks of treatment, patients were observed for clinical response: number of the acne lesions, Korea acne grading system (KAGS), global improvement, and occurrence of adverse reactions.



Results: During 4 weeks of treatment, nadifloxacin caused significant reduction in the number of inflamed papulo-pustular lesions and open/closed comedones. In addition, significant reduction of KAGS was observed. About 96% of patients showed clinical improvement in the overall evaluation of the therapeutic effect by physicians. All reported adverse events were mild.



Conclusion: This study shows that 1% nadifloxacin cream can be an effective and safe treatment for mild to moderate acne vulgaris.
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dc.language.isoko-
dc.titleClinical Efficacy and Tolerance of 1% Nadifloxacin Cream in the Treatment of Mild to Moderate Acne Vulgaris in South Korea-
dc.title.alternative경증 및 중등도의 한국인 여드름 환자에서 1% Nadifloxacin 크림(Nadixa(R))의 유효성 및 안전성 평가-
dc.typeArticle-
dc.subject.keyword1% nadifloxacin cream-
dc.subject.keywordAcne-
dc.subject.keywordTreatment-
dc.contributor.affiliatedAuthor이, 은소-
dc.type.localJournal Papers-
dc.citation.titleKorean journal of dermatology-
dc.citation.volume48-
dc.citation.number8-
dc.citation.date2010-
dc.citation.startPage665-
dc.citation.endPage671-
dc.identifier.bibliographicCitationKorean journal of dermatology, 48(8). : 665-671, 2010-
dc.relation.journalidJ004944739-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Dermatology
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