380 350

Cited 0 times in

Comparison of Clinical Characteristics between Acute and Chronic Acetylsalicylic Acid-Intolerant Urticaria

Other Title
아스피린 과민성 두드러기 환자들의 임상적 특성
Authors
김, 정은; 이, 진우; 성, 준모; 김, 주희; 최, 길순; 예, 영민; 남, 동호; 박, 해심
Citation
Chʿŏnsik mit alrerugi, 30(2):93-99, 2010
Journal Title
Chʿŏnsik mit alrerugi; Journal of asthma, allergy and clinical immunology; Korean journal of asthma, allergy and clinical immunology; 천식 및 알레르기
ISSN
1226-8739
Abstract
Background: Acute (AIAU) and chronic (AICU) acetylsalicylic acid (ASA)-intolerant urticaria are the major phenotypes of ASA hypersensitivity.



Objective: We compared clinical features, immunologic findings and a HLA marker between AIAU and AICU.



Method: We enrolled 232 patients with AIAU, 244 patients with AICU and 232 non-atopic normal controls (NC). Serum total and specific IgE to house dust mites (HDM) and Staphylococcal superantigens were measured by immunoCAPⓡ system. Serum myeloperoxidase, IL-8, IL-18 and TGF-β1 were measured by ELISA. We measured antinuclear antibody by the indirect immunofluorescence method, and antithyroglobulin, antimicrosomal antibodies, and IgG to cytokeratin 14 by ELISA. HLA-DRB1*1302-DQB1*0609 was analyzed by a high resolution technique.



Result: The atopy rate, and the levels of serum total and specific IgE to HDMs and TSST-1, and serum IL-18 and TGF-β1 were significantly higher in both AIAU and AICU groups than NC. There were no significant differences in the prevalence of autoantibodies between the AIAU and AICU patients. The prevalence of HLA-DRB1*1302-DQB1* 0609 was higher in both the AIAU and AICU patients.



Conclusion: Atopy is a common predisposing factor for both AIAU and AICU phenotypes. Associations with autoantibodies were suggested in the pathogenesis of AIAU as well as AICU. HLA-DRB1*1302-DQB1*0609 can be a genetic marker for both AIAU and AICU.
Keywords
Aspirin hypersensitivityUrticariaAtopyHLA
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
AJOU Authors
김, 정은김, 주희최, 길순예, 영민남, 동호박, 해심
Full Text Link
Files in This Item:
Journal of asthma allergy and clinical immunology_30(2)_93-99.pdfDownload
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse