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Measurement Specific IgE against Recombinant 16-kD and 19-kD Buckwheat Allergens for the Diagnosis of Buckwheat Allergy

DC Field Value Language
dc.contributor.author이, 재현-
dc.contributor.author이, 용원-
dc.contributor.author신, 유섭-
dc.contributor.author박, 해심-
dc.contributor.author홍, 천수-
dc.contributor.author박, 중원-
dc.date.accessioned2014-02-17T06:06:07Z-
dc.date.available2014-02-17T06:06:07Z-
dc.date.issued2010-
dc.identifier.issn1226-8739-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/9354-
dc.description.abstractBackground: Buckwheat (BW, Fagopyrum esculentum)-specific IgE (sIgE) measurement is crucial to diagnose BW allergy. However, clinical application is difficult due to a high false-positive rate. Previously we identified 16-kD 2S storage albumin and 19-kD vicilin-like protein as BW major allergens.



Objective: To investigate clinical usefulness of sIgE measurements against recombinant 16- and 19-kD BW allergens compared to the skin prick test and measurement of specific IgE against whole buckwheat (WBW) extract.



Method: Eleven BW allergic patients, 11 asymptomatic sensitizers to BW and 16 non-atopic subjects were enrolled. We performed the skin prick test, sIgE measurement against recombinant 16- and 19-kD BW allergens and WBW extract using a CAP system.



Result: In BW allergic patients, sIgE against WBW extract, r16- and r19-kD BW allergens were detected in 10, 5 and 9 patients, respectively. In asymptomatic sensitizers, sIgE against WBW extract, r16- and r19-kD BW allergens were detected in 9, 1 and 2 patients respectively. In ROC analysis, the AUC value of sIgE level was higher in r19-kD allergen than in r16-kD or WBW extract.



Conclusion: We suggest that CAP sIgE against r19-kD and r16-kD BW allergens can be a diagnostic marker to discriminate BW allergic patients from asymptomatic sensitizers in a clinical setting.
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dc.language.isoko-
dc.titleMeasurement Specific IgE against Recombinant 16-kD and 19-kD Buckwheat Allergens for the Diagnosis of Buckwheat Allergy-
dc.title.alternative메밀 알레르기 진단에 있어서 16-kD 및 19-kD 재조합 알레르겐 특이 IgE 측정의 유용성-
dc.typeArticle-
dc.identifier.urlhttp://www.allergy.or.kr/journal/view.html?book=Journal&start=0&scale=10&key=&key_word=&key1=Subject&key2=Subject&key3=Subject&key4=Subject&key_word1=%B8%DE%B9%D0+%BE%CB%B7%B9%B8%A3%B1%E2+%C1%F8%B4%DC%BF%A1+%C0%D6%BE%EE%BC%AD+16-kD+%B9%D7+19-kD+%C0%E7%C1%B6%C7%D5+%BE%CB%B7%B9%B8%A3%B0%D5+%C6%AF%C0%CC+IgE+%C3%F8%C1%A4%C0%C7+%C0%AF%BF%EB%BC%BA&key_word2=&key_word3=&key_word4=&adverb1=and&adverb2=and&adverb3=and&adverb4=and&Vol=&Num=&year1=&year2=&sort=Publisher_date&aut_box=Y&sub_box=Y&sos_box=Y&key_box=Y&pub_box=Y&abs_box=&mod=&uid=&multi%5B%5D=3103-
dc.subject.keywordBuckwheat-
dc.subject.keywordAllergy-
dc.subject.keywordRecombinant-
dc.subject.keywordAllergen-
dc.subject.keywordSpecific IgE measurement-
dc.contributor.affiliatedAuthor박, 해심-
dc.type.localJournal Papers-
dc.citation.titleChʿŏnsik mit alrerugi-
dc.citation.titleJournal of asthma, allergy and clinical immunology-
dc.citation.titleKorean journal of asthma, allergy and clinical immunology-
dc.citation.title천식 및 알레르기-
dc.citation.volume30-
dc.citation.number3-
dc.citation.date2010-
dc.citation.startPage209-
dc.citation.endPage215-
dc.identifier.bibliographicCitationChʿŏnsik mit alrerugi, 30(3):209-215, 2010-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
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